氨基胍对STZ糖尿病大鼠视网膜毛细血管超微结构的影响  

Influence of Aminoguanidine on Retinal Capillary Ultrastructure in Diabetic Rats

作　　者：庞东渤[1] 刘学政[1] 李艳芹[2] 刘玉玲[2] 杨光 吕品 

机构地区：[1]锦州医学院解剖学教研室,辽宁锦州121001 [2]锦州医学院电镜室,辽宁锦州121001 [3]辽河油田中心中心医院,辽宁盘锦12400

出　　处：《锦州医学院学报》2003年第3期8-10,共3页Journal of Jinzhou Medical College

基　　金：辽宁省自然科学基金资助项目 (编号 0 0 2 114 )

摘　　要：目的　观察病程 6月STZ糖尿病大鼠视网膜毛细血管超微结构的病理改变及氨基胍对超微结构改变的影响。方法　制备STZ糖尿病大鼠动物模型 ,随机分为正常对照 (CON)组、糖尿病 (DM )组及氨基胍 (AG)组。每组大鼠各 8只 ,饲养 6个月时处死 ,取大鼠视网膜进行电镜观察。结果　DM组视网膜周细胞、内皮细胞核染色质浓缩 ,边集 ,分布于核膜下 ;胞质内线粒体肿胀 ,变性 ,空泡化 ,胞浆消失 ;基底膜增厚。结论　氨基胍对STZ糖尿病大鼠视网膜毛细血管超微结构的损害有明显防治作用。Objective To observe the pathogenic changes of retinal capillary ultrastructure in diabetic rats and structure changes of aminoguanidine. Methods Animal models were induced by streptozocin and randomly divided into diabetic mellitus(DM) group aminoguanidine(AG)group and control group.The rats were killed at 6 months and their retinas were studied by electronic microscope. Results Ultrastructure of retinal capillary endothelial cells and pericyte were abnormal and it was more obvious in DM group than in AG group. Conclusions Aminoguanidine can effectively provent and cure the damages of retinal capillary ultrastructure in STZ-diabetic rats.

关 键 词：氨基胍 糖尿病视网膜病变 毛细血管 超微结构 大鼠 

分 类 号：R587.2[医药卫生—内分泌] R774[医药卫生—内科学]