国产盐酸加替沙星对临床常见致病菌的体外抗菌活性研究  

STUDIES ON ANTIBACTERIAL ACTIVITY OF DOMESTIC GATIFLOXACIN IN VITRO

作　　者：冯惠东[1] 郭毅[2] 王永祥[1] 金世香[1] 张永红[1] 

机构地区：[1]河北医科大学基础医学院微生物学与免疫学教研室,河北石家庄050017 [2]河北省药品检验所,河北石家庄050011

出　　处：《河北医科大学学报》2003年第4期211-213,共3页Journal of Hebei Medical University

摘　　要：目的评价国产盐酸加替沙星 (gatifloxacin)与司帕沙星 (sparfloxacin)对临床分离株的体外抗菌活性。方法采用琼脂稀释法测定最小抑菌浓度 (minimuminhibitoryconcentration ,MIC)。结果盐酸加替沙星对肺炎克雷伯菌、沙雷菌、不动杆菌、变形杆菌和产气肠杆菌有良好的抗菌活性 ,MIC50 均≤ 0 .0 91 2 μg/ml;其它敏感细菌依次分别为金黄色葡萄球菌 (MIC50 0 .1 4 9μg/ml)、表皮葡萄球菌 (MIC50 0 .8μg/ml)、铜绿假单胞菌 (MIC50 1 .4 5 2 μg/ml)、阴沟肠杆菌 (MIC50 1 .796 μg/ml)、粪肠球菌 (MIC50 6 .4 μg/ml)、大肠杆菌 (MIC50 1 5 .0 4 6 μg/ml)和枸橼酸杆菌(MIC50 2 9.788μg/ml)。盐酸加替沙星对所试菌株的抑菌作用均相当或高于阳性对照药司帕沙星 ,其中对大肠杆菌高 6倍 ,对表皮葡萄球菌高 3.4倍 ,对肺炎杆菌、变形杆菌和不动杆菌高 1倍。结论盐酸加替沙星对所试菌株有着较高的抗菌活性 ,为广谱抗菌药 ,在体外的抗菌作用优于或相当于司帕沙星 ,尤其是对大肠杆菌、表皮葡萄球菌、肺炎杆菌。ObjectiveThe antibacterial activities of domestic gatifloxacin in vitro were evaluated.MethodsMinimum inhibitory concentration was determined by agar disk dilution.ResultsThe gatifloxacin showed excellent efficiency against Klebsiellapneumoniae,Serratia marcescens,Acinetobaceter spp, Protens spp and Enterobacter aerogenes(MIC 50 ≤ 0.0912 μg/ml);The MIC 50 of gatifloxacin is 6 fold, 3.4 fold and 1 fold lower than that of sparfloxacin Escherichia coli, Staphylococcus epidermidis and Klebsiella pneumoniae, Protens spp, Acinetobaceter spp respectively.ConclusionThe antibacterial activities of gatifloxacin in vitro are similar or even stronger to that of sparfloxacin.

关 键 词：盐酸加替沙星 致病菌 体外 抗菌活性 琼脂稀释法 分离株 抗菌作用 

分 类 号：R978.19[医药卫生—药品]