甲氧氯普胺与多潘立酮联合应用预防150个产妇的剖宫产术后腹胀  

Metoclopramide combinded with domperidone in preventing postcesareon abdominal distension in 150 parturients

作　　者：李节良[1] 王捍东[1] 翟莹[1] 

机构地区：[1]莱州市人民医院妇产科,山东莱州261400

出　　处：《中国新药与临床杂志》2003年第7期413-414,共2页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :观察甲氧氯普胺与多潘立酮 2种胃动力药联合应用对剖宫产术后预防和减轻术后腹胀的效果。方法 :选择剖宫产产妇 30 0例 ,按手术顺序分成A ,B 2组。A为奇数 ,B为偶数各 15 0人。A为对照组 ,术后立即肌内注射维生素B110 0mg ,6h后给复合维生素B 2片 ,po ,tid ,餐前 30min ,至肛门排气停药 ;B组为试验组 ,剖宫产术后立即肌内注射甲氧氯普胺 10mg ,6h后给多潘立酮 10mg ,po ,tid ,餐前 30min ,至肛门排气停药。通过肛门排气时间观察疗效。结果 :B组显效 4 2 % ,有效 5 6% ,总有效率 98%。A组显效 8% ,有效 2 6% ,总有效率 34% ,2组比较差异有非常显著意义 (P <0 .0 1)。未出现锥体外系的不良反应 ,仅 2例出现轻微腹痛。结论AIM: To observe the effect of metoclopramide combined with domperidone in preventing and relieving postcesarean abdominal distension. METHODS: Three hundred parturients who underwent cesarean were divided into two groups. All of the patients in group A (control group) were given vitamin B 1 100 mg, im, just after cesarean and after 6 h, compound vitamin B 2 tables po, tid 30 min before diet. This administration continued until anus exhale. The patients in group B(experiment group) were given metoclopramide 10 mg, im, just after cesarean and after 6 h, given domperidone 10 mg, po, tid 30 min before diet. The adminstration continued until anus exhale. RESULTS: The preventive and curative effect in group B was better than that in group A. In group B the significant effective rate was 42 % and effective rate was 56 %, the total effective rate was 98 %, while in group A those were 8 %, 26 %, and 34 %, respectively. There was significant difference between group A and group B(P<0.01). There were no adverse reactions on extrapyramidal system. Only two patients had mild abdominalgia. CONCLUSION: Metoclopramide combined with domperidone can prevent or relieve the abdominal distension following cesarean ideally.

关 键 词：甲氧氯普胺 多潘立酮 多巴胺受体阻滞剂 剖宫产术 术后腹胀 肛门排气时间 

分 类 号：R975[医药卫生—药品] R719.8[医药卫生—药学]