自身免疫性甲状腺病巨噬细胞、NK细胞的免疫组化研究  

Immunohistochemical Study on Intrathyroidal Macrophages,Natural Killer Cells in Autoimmun(?) and Other Thyroid Diseases

作　　者：王坚[1] 王竹兰[1] 胡绍文[2] 王伯沄[2] 金伯泉[2] 

机构地区：[1]南京金陵医院内分泌科 [2]第四军医大学

出　　处：《江苏医药》1992年第9期466-468,共3页Jiangsu Medical Journal

摘　　要：本文采用APAAP法对自身免疫性甲状腺疾病及某些甲状腺其他疾病作免疫组化研究。发现除桥本甲状腺炎(HT)与非毒性甲状腺肿(NTG)在浸润单个核细胞中Ki-M8^+细胞的比例相差显著外,其余均无显著性差异。HT 的甲状腺中NK 细胞可能并不减少。Ki-M8^+细胞浸润程度与滤泡细胞HLA-DR 抗原的表达成正相关。Ki-M8^+细胞和NKH-1^+细胞多呈散在分布。在有破坏的HT甲状腺滤泡中常见NKH-1^+细胞,提示NK 细胞攻击甲状腺滤泡。37 thyroid specimens obtained from lunge calibre needle biopsy and surgery were studied by APAAP immunohistochemical technique.It was shown that the differences in infiltrating degree of macrophages(MΦ)and natural killer(NK)cells in different thyroidal diseases were not significant except for the MΦ between Hashimoto's thyro- iditis(HT)and nontoxic goiter.The proportion of Ki-M8^+ cells(MΦ)and NKH-1^+ cells (NK)diffusely distributed mononuclear cells were higher than those in lymphocytic aggregates in HT.The level of HLA-DR antigen expression on thyroid follicular cells was positively correlated with the proportion of Ki-M8^+ cells in thyroid mononuclear cells.NKH-1^+ cells were often seen within lumens or between thyroid cells of partially destroyed follicles of HT.It was deduced that NK cells might be related to the pathoge- nesis of HT.

关 键 词：甲状腺疾病 巨噬细胞 NK细胞 

分 类 号：R581.03[医药卫生—内分泌]