丝裂霉素外漏致组织损伤的实验研究  

Experimental Study on MMC Leakage-induced Tissue Injury

作　　者：朱艳萍[1] 高小海[2] 毛永荣[3] 

机构地区：[1]湖北省肿瘤医院肿瘤内科,湖北武汉430079 [2]湖北省肿瘤医院科研所,湖北武汉430079 [3]湖北省肿瘤医院病理科,湖北武汉430079

出　　处：《护理学杂志（综合版）》2003年第8期571-572,共2页Journal of Nursing Science

基　　金：湖北省肿瘤医院科研项目(KY 200006)

摘　　要：目的 探讨避免化疗药物外所引起永久性组织损伤的防治方法。方法 建立丝裂霉素(MMC)外漏动物模型(对照组),分别采用普鲁卡因、地塞米松(实验1组)和普鲁卡因、地塞米松、堆生素C、山莨菪碱(实验2组)作局部封闭。结果MMC外漏(对照组)后100％出现组织损伤。封闭后组织损伤程度实验2组明显轻于实验1组(P<0.05)。结论 普鲁卡因、地塞米松、维生素C、山莨菪碱四药联合封闭能有效减轻MMC渗漏造成的组织损伤。To study the method for avoiding drug leakage-induced permanent tissue injury. Methdos A MMC leakage animal model was established. The animals were divided into control group (model group). experimental group 1 (procarine+dexamethasone) and experimental group 2 (procarine+dexamethasone+vitamine C+ anisodamine). Results All animals developed tissue injure after MMC leakage (model group). After blocking, severity of tissue injury in experimental group 2 was milden than in experimental group 1 (P<0. 05). Conclusion Combined use of procarine. dexathasone, vitamine C and anisodamine could effectively alleviate MMC leakage-induced tissue injury.

关 键 词：丝裂霉素 局部渗漏 组织损伤 数据收集 

分 类 号：R979.1[医药卫生—药品] R471[医药卫生—药学]