中西药联合治疗异位妊娠30例  

Observation of curative effect of integrated chinese traditional and western medicine herbs in treating the ectopic pregnancy in 30 cases.

作　　者：曹玉民[1] 李建霞[1] 秦雪妮[1] 

机构地区：[1]青岛市第八人民医院,山东青岛266100

出　　处：《现代医药卫生》2003年第7期815-816,共2页Journal of Modern Medicine & Health

摘　　要：目的:观察甲氨喋呤(MTX)和米非司酮、中药联合治疗异位妊娠的效果。方法:51例符合保守治疗条件的异位妊娠患者分为A、B两组,A组30例,三种药物联合应用,即米非司酮150mg,一次顿服,MTX20mg静注×5天,同时服用中药7天,B组21例单用MTX20mg静注×5天,两组用药7天后测血(β-hCG)值观察其下降情况。结果:用药7天后A组血β-hCG为(235.9±93.7)IU/L,显著低于B组(301.9±71.6)IU/L,两者比较差异有显著性(P<0.01)。A组血β-hCG值下降≥30%者有26例,占86.67%,B组β-hCG值下降≥30%者有10例,占47.62%,A组治疗异位妊娠的成功率明显高于B组,两者比较差异有显著性(P<0.01)。结论:三种药物联合治疗异位妊娠安全、有效、疗效高,适用于生命体征平稳无剧烈腹痛、血β-hCG<2000IU/L,异位妊娠包块最大直径<6cm非破裂型异位妊娠,肝、肾和凝血功能正常是其适应症,可作为临床首选治疗方案。Objective:To observe the effect of combination of methotrexate and mifepristone and traditional Chinese medicine herbs intreating ectopic pregnancy.Methods:51 case were divided into group A and group B.Group A was treated with 150mg of mifepristone administered orally one time and 20 mg methotrexate intravenous drip for 5 days and traditional Chinese medicine herbs administered orally twice one day for 7 days.Group B received only 20mg methotrexate intravenous drip for 5 days as control group.The values of plasma β-hCG were measured after treating 7 days.Results:The values of plasma β-hCG after treating 7 days in group A(235.87±93.72)IU/L were significantly lower than those of group B(301.90±71.63)IU/L(P<0.01).Group A showed great differences in the success rate(86.67%),which was significantly higher than that of the group B(47.62%).Statistic analysis showed signigicant difference between group A and group B(P<0.01).Conclusion:The treatment of ectopic pregnancy with the combination of methotrexate and mifepristone and traditional Chinese medicine herbs is safe and effective with highly successful rate and minor side effects,It is suitable for the unruptured ectopic pregnancy with stable vital signs,serum β-hCG<2000 IU/L,ectopic mass<6cm in the largest dimension,but without acute abdominal pain.Normal function of liver,kidney and coagulation are mainly indications for the treatment of ectopic pregnancy.It may be used as first choice in treating ectopic pregnancy,especially to those who need to keep the reproductive funcion.

关 键 词：异位妊娠 中西药联合治疗 甲氨喋呤 米非司酮 

分 类 号：R714.22[医药卫生—妇产科学]