氟喹诺酮类抗菌素对已知高危心脏病患者猝死的影响  

Influence of fluoroquinolones on sudden death in patients with diagnosed high risk heart disease

作　　者：王兴元[1] 杨善进[1] 范利娟[1] 周红霞[1] 曹洪兵[1] 

机构地区：[1]解放军第359医院心血管内科,镇江212001

出　　处：《中国循证心血管医学杂志》2015年第5期682-683,686,共3页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的研究氟喹诺酮类抗菌素(fluoroquinolones,FLQs)对已知高危心脏病患者猝死的影响。方法选择1999年1月~2010年1月解放军第359医院心血管内科高危心脏病患者518例,男性213例,女性305例,年龄45~88岁。根据患者是否应用FLQs将患者分为使用组(n=78)和未用组(n=440)。经Holter证实的恶性心律失常患者进行随访调查,了解死亡原因和猝死情况。结果使用组78例,死亡42例,其中猝死者26例;未用组共440例,死亡124例,其中猝死者22例。使用组有2例心脏骤停发生后被复苏成功,但最后因多器官衰竭而死亡,本研究也归入猝死。FLQs使用组猝死发生率明显高于未用组(33.3%vs.5.0%),差异有显著统计学意义(P<0.01)。结论高危心脏病患者使用FLQs会导致猝死发生率增加。Objective To study the influence of fluoroquinolones(FLQs) on sudden death in patients with diagnosed high risk heart disease. Methods The patients(n=518, male 213, female 305 and aged from 45 to 88) were chosen from Jan. 1999 to Jan. 2010. All patients were divided, according to whether or not using FLQs, into FLQs group(n=78) and control group(n=440). The patients with malignant arrhythmia confirmed by Holter were followed up and surveyed, and the causes of death and incidence of sudden death were investigated. Results Of 78 patients in FLQs group, 42 died including 26 of sudden death, and of 440 patients in control group, 124 died including 22 of sudden death. In FLQs group, 2 patients were successfully resuscitated after sudden death, but finally died due to multiple organ failure and they were classified to sudden death patients. The incidence of sudden death was significantly higher in FLQs group than that in control group(33.3% vs. 5.0%, P<0.01). ConclusionWhen the patients with high-risk heart disease use FLQs, the incidence of sudden death will be increased.

关 键 词：喹诺酮类抗菌素 猝死 高危心脏病 

分 类 号：R541[医药卫生—心血管疾病]