血管内皮生长因子和雌二醇对卵巢过度刺激综合征的预测作用  

The Predictive Role of Vascular Endothelial Growth Factor and Estradiol in Infertile Patients with Ovarian Hyperstimulation Syndrome

作　　者：王庆一[1] 杨桂艳[1] 杨嫦玉[1] 湛冰[1] 杨如春[1] 

机构地区：[1]珠海市妇幼保健院妇科,珠海519000

出　　处：《四川大学学报（医学版）》2003年第3期565-567,共3页Journal of Sichuan University(Medical Sciences)

摘　　要：目的　探讨血管内皮生长因子 ( VEGF)和雌二醇 ( E2 )对卵巢过度刺激综合征 ( OHSS)的预测及在发病机理中的作用。方法　 5 1例高危患者分为 OHSS组 ( n=11)和非 OHSS组 ( n=40 ) ,测定高危患者 h CG注射日、取卵日血清 VEGF和 E2 水平以及取卵日卵泡液 VEGF水平 ,并与同期 3 0例非高危对照患者进行比较。结果　OHSS组在注射 h CG前 ,血清 VEGF水平与对照组无显著性差别 ( P>0 .0 5 ) ,注射后 OHSS组 VEGF水平明显升高 ( P<0 .0 1) ,显著高于对照组 ( P<0 .0 1) ;取卵日卵泡液 VEGF显著高于对照组 ( P<0 .0 1) ,且均显著高于血清各组 VEGF水平 ( P<0 .0 0 1)。OHSS组患者注射 h CG后 E2 水平较注射前明显升高 ( P<0 .0 1) ,并显著高于对照组( P<0 .0 1) ,非 OHSS者 E2 水平在注射 h CG前后变化不明显 ( P>0 .0 5 )。结论　取卵日 OHSS组血清和卵泡液VEGF水平明显高于对照组 ,表明 VEGF可能在 OHSS的发病中起重要作用 ,而在 h CG注射日对 OHSS无预测作用 ,但在 h CG注射后可作为预测 OHSS的标记物 ,如结合连续测定 E2 浓度 。Objective To determine the predictive values of vascular endothelial growth factor(VEGF) and estradiol (E 2) in patients with ovarian hyperstimulation syndrome (OHSS) and to go further into the relevant pathogenisis. Methods Blood samples were collected from 51 high risk patients and 30 control patients undergoing superovulation on the day of hCG administration and follicular fluid at the time of egg retrieval. The high risk poctients were divided into two groups 〔OHSS group (n=11) and non-OHSS group (n=40)〕 VEGF and E 2 were detected and then differences between the high risk groups and control group were analyzed. Results There was no significant difference in VEGF between high risk groups and control group on the day of hCG injection(P>0.05). After hCG administration, serum VEGF concentrations rose significantly in OHSS group (P<0.01). The serum and follicular fluid VEGF levels were obviously higher than those of the control group. The follicular fluid concentrations of VEGF were significantly higher than that of serum in every group (P<0.001). E 2 concentrations of OHSS group rose obviouly after hCG injection (P<0.01) and were significantly higher than those of the control group (P<0.01), but there was no statistically significant change in E 2 concentrations in non-OHSS groups (P>0.05). Conclusion The results from this study show that the serum and follicular fluid VEGF concentrations are significantly higher than those of control group on the day of ovum retrieval, indicating that VEGF may play an important role in the pathogenesis of OHSS. It cannot predict the risk of OHSS on the day of hCG administration, but it may be considered as a predictive marker for the development of OHSS after hCG administration. Serum VEGF concentrations in combination with consecutive E 2 measurements can assist in predicting OHSS.

关 键 词：血管内皮生长因子 雌二醇 卵巢过度刺激综合征 预测 

分 类 号：R711.75[医药卫生—妇产科学]