电突触耦合Chay神经元同步振荡的研究  

RESEARCH FOR SYNCHRONOUS OSCILLATION ON ELECTRICALLY COUPLED CHAY NEURONS

作　　者：葛曼玲[1] 郭鸿涌[1] 王广健[2] 颜威利[1] 

机构地区：[1]河北工业大学电气工程学院,天津300130 [2]皖淮北煤炭师范学院化学系,安徽淮北235000

出　　处：《生物物理学报》2003年第2期135-140,共6页Acta Biophysica Sinica

基　　金：天津市自然科学基金项目(023609211)

摘　　要：从微观解释异常神经元构建组织时癫痫样波形的相互制约关系对神经系统疾病的研究很有意义,而两神经元耦合特性的探索是重要的基础工作。采用Chay提供的Pacemaker神经元模型以电突触耦合来研究不同耦合强度对神经元动态时序的影响,并指出突触作用过程的混沌特征。给出并讨论了不同状态神经元相耦合时非线性振荡的数值计算结果,即:起搏神经元与处于冲动混沌状态神经元、处于冲动混沌和独态冲动状态的异常神经元、异常神经元与处于静息状态神经元的动态时序,还给出了部分相图以及Ca2+离子浓度变化的特点。神经元这种负载特性的讨论有助于研究在活组织中癫痫发作的机理、传输和控制。To study how the epileptiform waves are mutually affected is meaningful for the research of neural disease. And to investigate synchronous properties of coupling neurons is an important basis. The bursting dynamics of chay neuron model coupled by gap junction with different strength were ob-served and the chaotic characteristics were displayed. The numerical results of non-linear oscillation under different states of coupling neurons were analyzed, such as: pacemaker neuron and chaotic burst neuron, chaotic burst neuron and single burst neuron, abnormal neuron and resting neuron. Some phase portraits of coupling neurons and its dynamic features of Ca 2+ concentration change were provided. The work is helpful to our further research for the mechanism of epileptic seizure, epileptic wave propagation and control.

关 键 词：电突触耦合 神经元 同步振荡 癫痫 

分 类 号：R742.1[医药卫生—神经病学与精神病学]