人眼房水动力学系统的建模与仿真方法研究  

MODELING AND SIMULATION FOR THE DYNAMIC SYSTEM OF THE HUMAN EYE AQUEOUS HUMOR FLOW

作　　者：鞠颖[1] 王博亮[2] 吴世辉[3] 黄晓阳[2] 万明习[1] 

机构地区：[1]西安交通大学生物医学工程系,陕西西安710049 [2]厦门大学计算机系,福建厦门361005 [3]厦门大学医院,福建厦门361005

出　　处：《生物物理学报》2003年第2期207-212,共6页Acta Biophysica Sinica

基　　金：福建省科技重点项目(2002Y021)

摘　　要：为从宏观上应用工程方法进一步研究房水运行机理,提出了人眼前节房水流动系统的动力学仿真模型。依据目前眼科界较为公认的房水运行和眼压反馈机制建立系统构架,基于对眼科解剖学与生理学相关理论的分析、流体力学基本原理和临床参数进行系统辨识与参数确定。运用数字仿真的方法分别在正常生理平稳状况和激发试验状况下对模型进行了仿真运行,获得了和临床结论较为一致的结果。能较好地模拟房水运行机制,在与临床可测量参数一致的同时能获得一些不易测量的参数,为研究房水动力学提供依据。In order to research the mechanism of the aqueous humor flow macroscopically with en-gineering method, a dynamistic simulation model was built for the system of human eye's aqueous humor flowing. The frame of the model was built based on the ophthalmic accepted feedback mechanism of the aqueous humor flow and intraocular pressure. The transfer functions and the parameters were educed from the analysis of physiological theories, the basal elements of hydrodynamics, and the clinical parame-ters. This model has been digitally simulated for the normal physiological condition and the Challenge condition, and the results were coincided with clinical results. This model can simulate the mechanism of the aqueous humor flow and get the parameters some of which can't be easily measured clinically, and give the gist of aqueous humor flow. There isn't any report of this kind of model to research aqueous humor flow, and it is an initiating work.

关 键 词：房水动力学系统 仿真方法 眼压 数字仿真 动力学模型 眼睛 

分 类 号：R339.141[医药卫生—人体生理学] R318.01[医药卫生—基础医学]