乙型肝炎和相关肝病患者血清X抗原及其抗体的研究  被引量:2

SERO-PREVALENCE OF HBxAG AND ANTI-HBx IN PATIENTS WITH HEPATITIS B AND HB-RELATED DISEASES

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作  者:田琦琦[1] 王志明[1] 陈伟华[1] 李江[1] 郭朝平 张继锁[1] 谭复明[1] 吴在川[2] 

机构地区:[1]解放军第260医院 [2]解放军军事医学科学院

出  处:《解放军医学杂志》1992年第4期275-277,共3页Medical Journal of Chinese People's Liberation Army

摘  要:以重组的HBxAg和单克隆抗HBx作试剂,用酶联免疫法检测各类乙型肝炎和相关肝病的血清HBxAg和抗HBx。慢性活动性肝炎分别为10.8%和11.8%,肝硬变2.4%和4.9%,肝癌两者均阴性。急性肝炎的抗HBx可于恢复期转阴。HBxAg主要存在于有病毒复制标志的慢性病例,其消长与ALT平行,似与病变活动性有关。Serum HBxAg and anti-HBx were tested in the patients with acute and chronic hepatitis B and HB-related diseases, using enzyme immunoassay with recombinant HBxAg and monoclonal anti-HBx as reagents. HBxAg and anti-HBx were 10.8% and 11.8% in chronic active hepatitis, 2.4% and 4.9% in cirrhosis, respectively, and both were negative in hepatocellular carcinoma. The anti-HBx in acute hepatitis disappeared during the convalescence. HBxAg was mostly detected in chronic cases with viral replication markers, growing and declining with the alanine transaminase, which suggested that it was correlated with the pathological activity.

关 键 词:乙型肝炎 抗体 X抗原 

分 类 号:R512.620.3[医药卫生—内科学]

 

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