肉鸡腹水综合征发病学的氧应激机制及其防治  

Pathogenesis Implicating with Oxidative Stress and Prevention of Ascites Syndrome in Broiler

作　　者：李建喜[1] 杨志强[1] 王学智[1] 张世珍[1] 冯霞[2] 齐志明[1] 孟嘉仁[1] 孙维宏[1] 

机构地区：[1]中国农业科学院兰州畜牧与兽药研究所,甘肃兰州730050 [2]中国农业科学院兰州兽医研究所,甘肃兰州730046

出　　处：《中国兽医学报》2003年第4期372-374,共3页Chinese Journal of Veterinary Science

基　　金：国家自然科学基金资助项目 ( 3 9470 5 44 )

摘　　要：用高能高盐日粮结合环境因子诱发肉鸡腹水综合征 ,并在饲料中添加抗氧化性药物硒 (Se)和中草药对其防治 ,检测体内自由基及其相关指标。结果显示 :腹水症高发鸡群肝组织 FRs水平和血清丙二醛 (MDA)含量明显升高 ,Se-GSH- Px活力显著降低 (P<0 .0 5 ) ;在饲料中添加 Se和中草药能显著降低腹水症的发病率和死亡率 ,并提高 Se- GSH-Px活力、降低 FRs水平和 MDA含量 ,Se的作用强于中草药。结果提示 :缺氧引起的应激反应是肉仔鸡腹水综合征发病学的主要生理性因子 ,自由基在该病发生过程中起着重要作用 ;日粮中添加抗氧化药物硒和中草药能通过改善机体的抗氧化机能、清除体内过盛的 FRs。Ascites syndrome was induced from feeding a control diet with high energy and salt in chickens raised under the low ventilation environment.Some chickens were treated with the control diet containing selenium and Chinese traditional herbal medicine.Free radicals,Se glutathoine peroxidase(Se GSH Px),molonaldehyde(MDA) in blood and liver of broilers and ascitic indexes were examined.The results were as follows:Both free radicals level and MDA concentrations in ascitic chickens tissues were significantly higher(P<0 05),and Se GSH Px activity was lower(P<0 05) than that of control group.The morbidity and mortality of ascites syndrome lowered significantly by supplementing the selenium and Chinese traditional herbal medicine in diets(P<0 01).The results suggested that hypoxia stress may be a main factor for pathogenesis of ascites syndrome,and free radicals play an important role in the pathogenesis implicating with oxidative stress.Ascites syndrome can be prevented and treated by supplement of Se and CTHM in diets which can improve the antioxidant function of chickens by enhancing antioxidase activity and scavenging excessive free radicals.

关 键 词：肉鸡 腹水综合征 发病学机制 氧应激 防治 自由基 抗氧化药物 硒 中草药 饲料添加剂 

分 类 号：S858.31[农业科学—临床兽医学]