无机汞的鼠胎盘转运的研究  

STUDY ON THE PLACENTAL TRANSFER OF INORGANIC MERCURY IN PREGNANT RATS

作　　者：杨文秀[1] 金焕荣[1] 王凤兰[1] 丛丽娜[1] 王之章[2] 

机构地区：[1]沈阳医学院 [2]中国医科大学病理研究室

出　　处：《解放军预防医学杂志》1992年第4期266-268,共3页Journal of Preventive Medicine of Chinese People's Liberation Army

摘　　要：通过母鼠,胎盘和胎鼠血汞浓度测定和胎盘病理学检查,进一步研究无机汞的胎盘转运功能。将妊娠大鼠随机分为四组,皮下注射蒸溜水和HgCl_2溶液,剂量为0.6、0.3、0.15mg/kg。结果表明,HgCl_2各剂量组的母鼠、胎盘和胎鼠血汞浓度呈现明显的剂量—反应关系,两者比较有显著正相关。胎盘病理改变表现滋养层和血窦部组织被玻坏,证明氯化汞能经胎盘转运。To clarify the maternal-fetal transfer of inorganic mercury across the placenta, concentrations of mercury of maternal blood, placental blood and fetal blood in rat as well as pathological changes of placental tissue were determined. The pregnant rats were divided into 4 experimental groups randomly. Mercuric chloride (0.15, 0.30, 0.60mg/kg) and distilled water were injected into the pregnant rats daily within 7th～16th days. The results showed that there was positive correlation between the concentrations of mercuric chloride in maternal and placental (or. maternal and fetal, place- ntal and fetal) blood. A clear dose-effect relationship was indicated. The pathological changes showed that the structure df trophoblast and blood sinus were destructed. It may be concluded that mercuric chloride can be transfe- red through the transplacental route.s

关 键 词：氯化汞 血汞浓度 胎盘转运 

分 类 号：R135.13[医药卫生—劳动卫生]