缬沙坦治疗肾性高血压的临床观察  

Clinical study of valsartan for renal hypertention

作　　者：徐向明[1] 王世明[1] 

机构地区：[1]山东临沂市人民医院,山东临沂276003

出　　处：《宁夏医学杂志》2003年第8期469-470,共2页Ningxia Medical Journal

摘　　要：目的　观察缬沙坦对肾性高血压的降压效果及对 2 4小时尿蛋白定量、肌酐、肌酐清除率、肝功能、电解质的影响。方法　 12 0例肾性高血压患者口服缬沙坦 80 - 16 0mg/d ,治疗 8周 ,治疗前后观察血压变化 ,2 4小时尿蛋白定量、肝功能、电解质变化。结果　缬沙坦治疗后血压明显下降 ,2 4小时蛋白尿明显减少 ,肝功能、电解质无变化。结论　缬沙坦对肾性高血压有较好的降压作用 ,且能降低尿蛋白 ,有一定的靶器官保护作用 ,是一种安全有效的降压药。Objectives To investigate the antihypertension efficacy of valsartan and it's effects on the hepatic and renal functions and serum electrolyte and creatinine clearence,serum creatinine.Methods 120 patients with renal hypertension were given valsartan 80-160 mg per day for a couse of 8 weeks.Before and after vasartan treatment,we made comparateve study of blood pressure,hepatic and renal functions,serum electrolyte.Results There was significant difference between before and after vasartan treatment in blood pressure and the uric protein in 24h.Conclusions Valsartan can decrease renal hypertention and protect renal function,is a safety,effective drug.

关 键 词：缬沙坦 肾性高血压 肾功能衰竭 

分 类 号：R544.14[医药卫生—心血管疾病]