盐酸环丙沙星的合成及工艺改进  

Preparation and Improvement on Production Technology of Ciprofloxacin Hydrochloride

作　　者：李灵芝[1] 陈海宽[1] 刘巧云[1] 李祖文[1] 

机构地区：[1]太原制药厂,山西太原030021

出　　处：《山西大学学报（自然科学版）》2003年第3期241-243,共3页Journal of Shanxi University(Natural Science Edition)

摘　　要：为降低盐酸环丙沙星的生产成本,提高市场竞争力,对它的合成工艺作了改进.介绍了以氟氯苯乙酮(2,4 二氯 5 氟苯乙酮)为起始原料合成盐酸环丙沙星,且在中间体1 环丙基 7 氯 6 氟 1,4 二氢 4 氧代喹啉 3 羧酸与哌嗪缩合后,以醇水混合物代替水进行后处理,使成本进一步降低.在保证质量的情况下,总收率达52.28%.This method made a improvement on production technique,to reduce manufacture cost of ciprofloxacin hydrochloride,and increase competition ability for market.In this paper,ciprofloxacin hydrochloride was synthesized from 2,4dichloro5fluoroacetophenone.After 1cyclopropyl7chloro6fluoro1,4dihydro4oxo3quinolinecarboxylic was combined with piperazine,resultant of reaction was treated with a mixture of isoamylol and water instead water.The good yield(52.28 %) can be ensured with high qualit product.

关 键 词：盐酸环丙沙星 合成工艺 氟氯苯乙酮(2 4-二氯-5-氟苯乙酮) 缩合反应 抗菌药物 

分 类 号：R978.1[医药卫生—药品] TQ465[医药卫生—药学]