小剂量叶酸对预防神经管畸形再发生作用的研究  

Effects of folic acid on the prevention of recurrent fetal NTDs.

作　　者：赵晓岚[1] 叶国玲[1] 郑军 楚雍烈[3] 刘琪[1] 蔡晓宁[1] 

机构地区：[1]西安交通大学第二医院遗传研究室,陕西西安710004 [2]陕西省妇幼保健院遗传室,陕西西安710003 [3]西安交通大学医学院微生物教研室,陕西西安710061

出　　处：《中国儿童保健杂志》2003年第4期226-227,共2页Chinese Journal of Child Health Care

基　　金：西安交通大学重点科研培植项目 (PZ0 91 )

摘　　要：【目的】　探讨小剂量叶酸片 (斯利安 )对神经管畸形 (NTDs)再发生的预防效果。　【方法】　 2 2 9例有NTDs妊娠史的已婚育龄妇女作为观察组 ,从孕前 3个月开始口服斯利安 ,直至妊娠满 3个月。对照组为有NTDs妊娠史 ,但妊娠前后从未服用斯利安。比较观察组与对照组NTDs再发生率。　【结果】　观察组有 8例再次发生NTDs,再发生率为 3 .0 0 %;对照组有 9例发生NTDs ,再发生率为 14 .0 0 %。NTDs再发生率观察组明显低于对照组 ,两者相比 ,差异有非常显著性 (P <0 .0 1)。　【结论】　斯利安预防NTDs再发生有非常显著的效果。To investigate the effects of folic acid on the prevention of recurrent fetal neural tube defects(NTDs). 229 women with a history of fetal NTDs assigned as monitoring group began to take 0.4～0.8 mg folic acid every day at least three months until the end of the first trimester. 69 women with a history of fetal NTD who did not intake any folic acid before or during the pregnancy were assigned as control group.The rate of fetal NTDs recurrence was compared. The rate of fetal NTDs recurrence in the monitoring groups(3.00%) was much lower than that of control group(14.00%).There was extramely significant difference between two groups. [Conclusion] Folic acid is really effective in the prevention of fetal NTDs recurrence.

关 键 词：神经管畸形 斯利安(小剂量叶酸片) 

分 类 号：R172[医药卫生—妇幼卫生保健]