海藻抗A-549和HL-60肿瘤细胞及抗菌活性研究  

Anticancer and Antibacterial Activity of the Methanol Extracts from Chinese Algae

作　　者：牛荣丽[1] 范晓[1] 韩丽君[1] 李宪璀[1] 

机构地区：[1]中国科学院海洋研究所,山东青岛266071

出　　处：《中国海洋药物》2003年第4期1-4,共4页Chinese Journal of Marine Drugs

基　　金：863计划(项目编号:2001AA620403);国家自然科学重点基金(项目编号:29932030);中国科学院海洋研究所创新前沿基金(项目编号:L410225102)

摘　　要：目的:为了从海藻中寻找天然药物活性前体。方法:对山东沿海的 39种海藻的甲醇提取物进行了抗肿瘤(肿瘤细胞A-549和HL-60)及抗菌(金葡菌、大肠杆菌和白色假丝酵母菌)活性筛选。结果:抗肿瘤活性研究中,海藻提取物表现出较好的活性,19种对HL-60有抑制作用,34种对A-549有抑制作用。其中,石花菜、萱藻和小粘膜藻对2种肿瘤细胞的抑制率均大于80％;而三叉仙菜和绳藻的抑制率均大于90％。在抗菌活性实验中,海藻提取物的最低抑菌浓度均大于 20mg·L^(-1)。结论:海藻作为抗肿瘤活性前体的来源,值得深入研究。Objective To verify the anticancer and antibacterial activity of extracts from Chinese marine algae. Methods methanol extracts of 39 species belonging to the classes Phaeo-phyceae, Rhodophyceae and Chlorophyceae were assayed. Results The results showed that the extracts of Gelidium amansii, Scytosiphon lomentarius and Leathesia nana show more than 80% inhibition against both cancer cells, esp. the extracts of Ccramium kondoi and Chorda filum with 90% inhibition higher; while the MIC of all extracts were over 20mg · L-1. Conclusion Chinese algae merit further investigation in anticancer activity.

关 键 词：海藻 活性筛选 抗肿瘤 抗菌 

分 类 号：R931.711[医药卫生—生药学]