O1/O139新型霍乱疫苗口服免疫动物后的自动免疫保护及被动保护试验研究  

Passive and active immno-protection tests with a new type of oral Cholera O1/O139 Vaccine

作　　者：陈翠萍[1] 宣俊文[1] 王永谦[1] 杨朝晖[1] 

机构地区：[1]兰州生物制品研究所,兰州730046

出　　处：《微生物学免疫学进展》2003年第3期18-21,共4页Progress In Microbiology and Immunology

摘　　要：O1/O139霍乱口服疫苗是一种新型疫苗。本文通过 2种不同途径免疫动物 ,检测血清抗菌抗体和肠道分泌性IgA抗体以及保护力试验 ,并探讨了它们之间的关系。通过家兔肠袢试验和细胞四甲基偶氮唑盐 (MTT)试验检测免疫后抗血清的被动保护作用。试验提示 :在霍乱的保护性免疫应答中 ,除粘膜免疫可能占主导作用外 。Oral O1-O139 cholerae vaccine is a new vaccine.This paper reported that animals were immunized with two different route, the antibacterial antibody in serum and secretory antibody in intestine were tested as well as the protective experiment was performed The relationships between them were also discussed.Passive protection effects were tested by rabbit ligated intestinal loop experiment and MTT experiment.The results showed that mucosa immune might have important effect while the antibacterial antibody in serum also have a certain action.

关 键 词：霍乱疫苗 保护性免疫 粘膜免疫 

分 类 号：R392[医药卫生—免疫学]