抗惊厥药超敏反应综合征——附9例报告  

Anticonvulsant Hypersensitivity Syndrome: Report of Nine Cases

作　　者：张国学[1] 王丹[1] 郭红卫[1] 李定[1] 黎兆军[1] 史建强[1] 李顺凡[1] 吴志华[1] 

机构地区：[1]广东医学院附属医院皮肤科,广东湛江524001

出　　处：《岭南皮肤性病科杂志》2003年第2期69-71,共3页Southern China Journal of Dermato-Venereology

摘　　要：目的:报告9例抗惊厥药超敏反应综合征的病例并回顾有关文献。方法:分析我科1996年～2002年间住院9例抗惊厥药超敏反应综合征患者临床特点和治疗,简要综述有关文献。结果:其中1例表现为麻疹样型,5例重症多形红斑(SJS),5例中毒性表皮坏死松解症(TEN),其中2例由SJS演变而来,所有病例均治愈。结论:本综合征可能与抗惊厥药的代谢产物氧化芳香烃有关。系统性皮质类固醇的治疗是必需的,并联合静脉营养、静脉补液、减轻疼痛和眼睛护理,静脉丙种球蛋白冲击治疗在部分病例有较好的治疗作用。Objective:To understand the clinical features, treatment and pathogenosis of anticonvul-sant hypersensitivity syndrome and litercture reviewed. Methods: Nine cases with anticonvulsant hyper-sensitivity syndrome that were hospitalized form 1996 to 2002 were analyzed. Results: Among them 1 case was morbilliform, SJS were 5 and TEN were 5 (2cases were evolved from SJS) , all cases were cured. Conclusion: This syndrome may be related to arene oxide metabolies of anticonvulsants. Pharmacological treatment was essentially based on systemic corticosteroids in association with intravenous nutrition -, intravenous fluid augmentation % pain relief and ocular care, intravenous immunoglobulins plaied the rapeutic role in some cases.

关 键 词：抗惊厥药超敏反应综合征 病例 麻疹样型 重症多形红斑 中毒性表皮坏死松解症 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]