苓丹片、青蒿琥酯对系统性红斑狼疮患者IL-2与sIL-2R影响的研究  

The Study of the Effect of Lingdanpian and Qinghaohuzhi on IL-2 and SIL-2R in SLE Patients

作　　者：张剑勇[1] 钟嘉熙[2] 彭胜权[2] 张奉学[2] 

机构地区：[1]深圳市中医院 [2]广州中医药大学

出　　处：《河南中医学院学报》2003年第2期38-39,共2页Journal of Henan University of Chinese Medicine

基　　金：广东省科委重点科技攻关项目 (96 0 2 1);广东省中医药管理局资助课题 (96 0 32970 74 )

摘　　要：目的 :进一步研究系统性红斑狼疮 (SLE)的免疫发病机理。方法 :按抽签法分治疗组、对照组 ,对 4 5例SEL患者白细胞介素 (IL - 2 )活性及血清可溶性白细胞 2受体 (sIL - 2R)水平进行检测 ,用苓丹片、青蒿琥酯进行干预。结果 :SLE患者IL - 2活性降低 ,而sIL - 2R水平升高 ,证实机体免疫调节机能严重紊乱。苓丹片能降低sLR水平 ,增强IL - 2活性 ,使SLE患者内环境紊乱的免疫功能趋向平衡。结论 :苓丹片配青蒿琥酯对机体免疫功能具有双向调节作用 。Objective: To study further the pathogenic mechanism of SLE. Method: 45 patients were randomly divided into treatment group and control group to test IL 2 activity and SIL 2R level. Result: It shows a lowered IL 2 activity but a raised SIL 2R level, proving a disordered immunoregulaion. Lingdanpian can decrease SLR level and increase IL 2 activity so that the disordered immunoregulation is restored. Conclusion: When Lingdanpian was used in combination with Qinghaohuzhi, it has a dual regulation of immunologic function, so that immunosuppressant such as hormone will not depress immune response.

关 键 词：苓丹片 青蒿琥酯 系统性红斑狼疮 IL-2 SIL-2R 影响 研究 

分 类 号：R259.932.4[医药卫生—中西医结合]