医用透明质酸钠预防肠粘连松解术后再次粘连的实验研究  

The experimental study on prevention action of natrium hyaluronic acid on intestinal adhesion after enterolysis

作　　者：孙鸿斌[1] 杨关根[1] 

机构地区：[1]杭州市第三人民医院肛肠科,310009

出　　处：《浙江临床医学》2003年第7期489-490,共2页Zhejiang Clinical Medical Journal

摘　　要：目的 探讨医用透明质酸钠对肠粘连松解术后再次粘连的预防作用。方法 35只大鼠制作肠粘连模型 ,于术后第7d剖腹观察粘连情况 ,选择发生I～II级粘连的大鼠20只分成A、B两组 ,每组各10只 ,A组将粘连处松解后即关腹 ,B组将粘连处松解后于创面处注射医用透明质酸钠后关腹。二次手术后第7d处死动物 ,观察各组肠粘连情况 ,并做统计学分析。结果 两组粘连分级差异有显著性意义(p<0.01)。结论 医用透明质酸钠可减少肠粘连松解术后再次粘连的程度。Objective To investigate the prevention action of natriumhyaluronic acid on intestinal adhesion after enterolysis. Methods The model of intestinal adhesion was set up in35rats.All rats were cut the belly open and observed the condition of intestinal adhesion in7th day postoperative.The20rats of intestional adhesion I-II degree were selected and randomly divided into A and B groups,each group has10rats.Enterolysis was operated in the rats of group A,but in the rats of group B,not only enterolysis was operated,but natrium hyaluronic acid was sprinkled on the surface of wound.After7days the rats were killed and observed the condition of intestinal adhesion.Thenstatistical analysis was been done. Results The intestinal adhesion score had significant difference in the rats of group A and B(p<0.01). Conclusion Natrium hyaluronic acid could reduce the degree of intestinal adhesion after enterolysis.

关 键 词：医用透明质酸钠 预防 肠粘连 松解术 术后再次粘连 实验 高分子粘多糖 

分 类 号：R656.7[医药卫生—外科学]