霉酚酸酯对弥漫增生型狼疮性肾炎患者的疗效观察  

Clinical Study of Mycophenolate Mofetil in Patients with Diffuse Proliferative Lupus Nephritis

作　　者：刘国平[1] 黄九香[1] 林琳[1] 

机构地区：[1]内蒙古自治区医院肾内科,呼和浩特010017

出　　处：《中国中西医结合肾病杂志》2003年第7期386-388,共3页Chinese Journal of Integrated Traditional and Western Nephrology

摘　　要：目的 :比较霉酚酸酯 (MMF)和环磷酰胺 (CTX)冲击疗法治疗Ⅳ型狼疮性肾炎的疗效及不良反应。方法 :A组 2 0例 ,间断性CTX冲击疗法联合激素 1mg·kg-1·d-1治疗 ;B组 2 0例 ,MMF联合激素治疗。随访 12个月。结果 :CTX组、MMF组治疗LN均能降低蛋白尿、血尿 ,改善肾功能和免疫指标 ,两组无统计学意义 (P >0 .0 5 ) ,但MMF组治疗效果优于CTX组。不良反应 ,MMF组明显低于CTX组 (P <0 .0 5 )。结论 :CTX、MMF都能有效地控制狼疮性肾炎 。Objective:To evaluate the therapeutic effect and side-effect between pulse Cyclophosphamide(CTX) therapy and mycophenolate mofetil (MMF) in lupus nephritis.Methods:A group(CTX group):20 patients were given intravenous CTX pulse plus oral prednisone 12 months.B group(MMF group):20 patients were given MMF and oral prednisone for 12 months. Patients in two groups were compared in age, sex distribution,severity of renal damage.Results:Both CTX and MMF reduced proteinuria and hematuria and improved renal function and immune indexes. CTX and MMF were effective on inhibition of autoantibodies production( P >0.05).Therapeutic effect of MMF group were better than CTX group.Side- effects of MMF group were less than those in CTX group( P < 0.05 ).Conclusion:For the treatment of lupus nephritis, the combination of MMF and prednisone is as effective as the regimen of CTX and prednisone but less toxicity.

关 键 词：霉酚酸酯 弥漫增生型狼疮性肾炎 疗效 临床观察 不良反应 环磷酰胺 

分 类 号：R593.242[医药卫生—内科学] R979.5[医药卫生—临床医学]