眼底造影荧光强度的计算机定量分析  

Computer-Assisted quantitative analysis of fluorescein leakage

作　　者：李付亮[1] 阴正勤[1] 孟晓红[1] 

机构地区：[1]第三军医大学西南眼科医院,重庆400038

出　　处：《激光杂志》2003年第4期85-86,共2页Laser Journal

摘　　要：目的 :建立眼底血管荧光造影 (fundusfluoresceinangiography ,FFA)中荧光强度定量图像分析方法 ,以评价眼底病变的病变程度和预后。方法 :分析湿性增龄性黄斑变性 (age -relatedmaculardegeneration ,AMD)患者FFA图像脉络膜新生血管膜 (choroidalneovascularizition ,CNV)渗漏强度在造影各期的变化趋势 ,分析正常眼底后极部 6.2 0mm2 区域的FFA荧光强度在造影各期的变化趋势 ,二者进行比较 ,验证荧光强度定量分析方法的客观性、有效性和实用性。结果 :湿性AMD患者的FFA图像CNV荧光素渗漏强度造影各期均显著高于正常眼底后极部 6.2 0mm2 区(P <0 .0 5或P <0 .0 1) ,动静脉期至 72 0秒差别具有非常显著性意义 (P <0 .0 1)。 180秒～ 3 0 0秒差别最明显。结论 :对眼底疾病的病变程度和预后进行评估 ,荧光强度计算机定量图像分析方法是比较客观。objective:To develop a computer-assisted method for quantity of intensity and area of Fluorescein leakage of fundus fluorescein angiography(FFA),in order to evaluate level and prognosis of fundus diseases.Methods:The mean gray of normal macular rounded 6.2mm 2 region and CNV lesion in exudative age-related macular degeneration (AMD)were measured and compared,to confirm usefulness,utility and objective effect of the measurment.Results:Comparing with normal eyes,we found gray scale level of AMD group was higher than normal group in each phase of FFA.(The difference was significant.P<0.05 or P<0.01).Conclusions:Computer-assisted method for quantity of intensity and area of fluorescein leakage is useful for evaluating level and prognosis of fundus diseases.

关 键 词：眼底血管荧光造影 定量分析 增龄性黄斑变性 计算机 FFA 荧光强度 

分 类 号：R816.97[医药卫生—放射医学]