重组人白细胞介素-2和干扰素-γ对老年性慢性阻塞性肺疾病患者稳定期自然杀伤细胞活性的调控  

Regulation of natural killing cell activity by recombinant human interleukin-2 and interferon-γ in the old chronic obstructive pulmonary disease at its stable phase.

作　　者：马珍[1] 李成海[1] 

机构地区：[1]河南省人民医院检验科,郑州450003

出　　处：《中国综合临床》2003年第9期801-802,共2页Clinical Medicine of China

摘　　要：目的探讨注射用重组人白细胞介素 2 (IL 2 )、干扰素 γ(IFN γ)在体内对老年性慢性阻塞性肺疾病 (COPD)稳定期患者NK细胞活性的影响。方法对老年COPD稳定期患者IL 2、IFN γ治疗组各 30例以及健康老年组 30例的NK活性进行检测。结果老年性COPD患者稳定期NK细胞活性明显低于正常对照组 (P <0 .0 1) ;IL 2、IFN γ在体内能明显提高老年性COPD患者的NK活性。结论老年性COPD患者稳定期NK活性对IL 2、IFN γ有明显的依赖性 ;IL 2、IFN γ对老年性COPD患者稳定期NK活性有调控作用。Objective To investigate the effect of the recombinant human interleukin 2(IL 2) and interferon γ(IFN γ) on natural killing(NK) cell activity in the old chronic obstructive pulmonary disease(COPD) at its stable phase. Methods The activity of NK cell was determined in 30 COPD cases at its stable phase who were treated by IL 2 and IFN γ, respectively, as well as in 30 healthy old cases. Results NK cell activity in the old COPD at its stable phase was remarkably lower than that in the control group(P<0.01). IL 2 and IFN γ could increase the NK cell activity in the old COPD patients. Conclusion NK activity in the old COPD at its stable phase is apparently dependent on IL 2 and IFN γ. IL 2 and IFN γ can regulate NK activity in the old COPD patients at its stable phase.

关 键 词：慢性阻塞性肺疾病 白细胞介素-2 干扰素-Γ 

分 类 号：R563.9[医药卫生—呼吸系统]