Livin——癌症治疗的新靶点  

Livin——Potential target for cancer treatment

作　　者：张华东[1] 袁守军[1] 陈惠鹏[1] 

机构地区：[1]军事医学科学院放射医学研究所,北京100850

出　　处：《中国药理学通报》2003年第8期845-847,共3页Chinese Pharmacological Bulletin

摘　　要：Livin是IAPs(inhibitorsofapoptosisproteins,IAPs)蛋白家族的新成员 ,有BIR和RING指结构域 ,能够与Caspas es蛋白结合 ,抑制其介导的细胞凋亡。它在大多数正常成人组织中不表达、在一些肿瘤细胞中的高表达 ,与肿瘤的关系为人们所关注 ,是肿瘤治疗的潜在靶点。Livin is a novel member of IAPs (inhibitors of apoptosis protein) family, which is expressed highly in a variety of tumors but not in majority of normal tissues. This protein contains a BIR domain and a RING finger domain just like other members of IAPs. It will be of great sigificance to investigate the relationship between Livin and tumors, and it might be a potential target for anti-cancer drugs.

关 键 词：LIVIN 凋亡 肿瘤治疗 

分 类 号：R329.25[医药卫生—人体解剖和组织胚胎学] R341[医药卫生—基础医学]