绞贞汤治疗放、化疗引起白细胞减少518例临床研究——附50例细胞形态学改变的分析  

Clinical observation on Jiaozhen decoction in treating 518 cases of leukocytopenia caused by radiotherapy and chemotherapy

作　　者：郝增来[1] 陈志峰[2] 斯重阳[1] 刘德[1] 刘倩[3] 邵淑琴[4] 刘艳坤[4] 刘少翔[2] 

机构地区：[1]河北医科大学第四医院,石家庄050011 [2]河北省肿瘤研究所,石家庄050011 [3]河北医科大学第二医院,石家庄050051 [4]河北省石家庄市桥东区医院,石家庄050011

出　　处：《河北中医》2003年第8期570-572,共3页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的　探讨自拟绞贞汤或绞贞冲剂治疗放、化疗引起白细胞减少的疗效 ,及其对白细胞形态学变化的影响。方法　 6 18例放、化疗引起白细胞减少患者随机分为 3组 ,即绞贞汤 (治疗 )组 5 18例、焦三仙对照组 5 0例和鲨肝醇、维生素B4西药组 5 0例 ,观察 3组临床疗效及白细胞回升情况 ;并对 5 0例白细胞低于3.9× 10 9 L末梢血涂片进行细胞形态学分析 ,对 2 5例白细胞减少为 (0 .7～ 3.9)× 10 9 L患者应用绞贞汤或绞贞冲剂治疗前后的细胞形态学改变进行观察。结果　①绞贞汤组白细胞回升至 4.0× 10 9 L及以上者时间、例数及总有效率分别与西药组和对照组比较 ,均有显著性差异 (P <0 .0 0 1) ;② 5 0例白细胞减少患者细胞形态学分析主要为粒细胞绝对值减少、中性粒细胞有中毒性颗粒、单核细胞与淋巴细胞增多等 ;③绞贞汤或绞贞冲剂治疗白细胞减少为 (0 .7～ 3.9)× 10 9 L 2 5例 ,白细胞均回升至 (4.3～ 6 .7)× 10 9 L。结论　绞贞汤或绞贞冲剂治疗放、化疗引起的白细胞减少疗效较好 ,且无任何副作用 ,便于临床推广应用。Objective To investigate the therapeutic effect of Jiaozhen decoction and Jiaozhen infusion on leukocytopenia caused by radiotherapy and chemotherapy, and to observe its effect on morphological changes of white blood cells (WBC).Methods 618 patients with leukocytopenia were randomly divided into three groups, including Jiaozhen decoction treatment group 518 cases, Jiaosanxian control group 50 cases and western medicine group (Shaganchun and Vitamin B 4) 50cases.The therapeutic effects of three groups were observed. The WBC morphological characters of 50 patients whose WBC were decreased to below 3.9×10 9/L were analyzed by peripheral blood smear, and the WBC morphological changes of 25 patients whose WBC were decreased to (0.7～3.9)×10 9/L were observed before and after treatment by Jiaozhen decoction or Jiaozhen infusion. Results ①The time, case number and total effective rate in Jiaozhen decoction group whose WBC were increased to 4.0×10 9/L were significantly different from those of western medicine group and Jiaosanxian control group (P<0.001).② The morphological characters in 50 patients with leukocytopenia were mainly the decrease of granulocytes, increase of monocytes and lymphocytes, and toxic granules in neutrophils. ③ The WBC of 25 patients with leukocytopenia (0.7～3.9×10 9/L) were increased to (4.3～6.7×10 9/L).Conclusion Jiaozhen decoction and Jiaozhen infusion are effective in treating leukocytipenia caused by radiotherapy and chemotherapy, without any side effect, and which is easy to be widely used in clinic.

关 键 词：白细胞减少 细胞学 绞贞汤 中医药疗法 

分 类 号：R557.105[医药卫生—血液循环系统疾病] R243[医药卫生—内科学]