薄荷醇及其二组分系统对5-氟脲嘧啶经皮渗透和贮库效应的影响  

Effects of l-menthol and its binary systems on the percutaneous penetration and the deposit effect of 5-fluorouracil

作　　者：王晖[1] 许卫铭[1] 

机构地区：[1]广东医学院药理学教研室

出　　处：《中国临床药理学与治疗学》2003年第4期422-424,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：广东省中医药管理局资助项目 (№ 98418) ;广东省卫生厅资助课题(№A2 0 0 0 490 )

摘　　要：目的 :探讨薄荷醇及其二组分系统对氟脲嘧啶 (5 FU)经皮渗透和贮库效应的影响。方法 :在离体透皮吸收装置上 ,测定不同时间 5 FU的透过量 ,计算累积透过量、渗透系数和增渗倍数 ,并考察其贮库效应。结果 :不同浓度薄荷醇对 5 FU经皮渗透均有明显的促进作用 ,其增渗倍数分别为 1.2 5、1.4 5和 1.37倍 ,其中含 2 %浓度的薄荷醇组作用最强 ;含 2 %和 4 %薄荷醇的组有显著的贮库效应。几种促透剂单独应用或与薄荷醇联合应用时 ,5 FU的经皮渗透均有显著或极显著的增加。结论 :薄荷醇及其二组分系统能显著增强 5 FU经皮渗透 ,加强其贮库效应。AIM: To study the effects of l-menthol and its binary systems on percutaneous penetration and deposit effects of 5-fluorouracil (5-FU). METHODS: Percutaneous absorption experiment was performed on the apparatus of isolated skin, penetrated amounts of different times of 5-FU were determined, the cumulate penetrated amounts and permeation rates and increased permeation times were calculated, and the deposit effect of 5-FU was investigated. RESULTS: L-menthol of different concentrations could significantly enhance the percutaneous penetration of 5-FU, its increased permeation times were 1.25 and 1.45 and 1.37 times respectively,and the action of 5-FU with 2% l-menthol was the strongest. 5-FU with 2% and 4% l-menthol had a marked deposit effect. When some kinds of enhancers were used alone or combined with l-menthol, the percutaneous penetration of 5-FU had a significantly increase. CONCLUSION: L-menthol and its binary systems can markedly promote the percutaneous penetration and the deposit effect of 5-FU.

关 键 词：药理学 薄荷醇 二组分系统 5—氟脲嘧啶 渗透系数 增渗倍数 贮库效应 

分 类 号：R285.5[医药卫生—中药学]