PHBV/Sol-gel Bioglass多孔材料在模拟生理溶液中的化学反应研究  

Chemical Reaction of PHBV/Sol-gel Bioglass Foams for Born Tissue Engineering in Simulated Body Fluid

作　　者：郑裕东[1] 王迎军[1] 陈晓峰[1] 任耀彬[1] 吴刚[1] 

机构地区：[1]华南理工大学材料学院,广州510641

出　　处：《高等学校化学学报》2003年第7期1325-1328,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金重点项目 (批准号 :5 9932 0 5 0 ) ;广东省自然科学基金 (批准号 :990 6 2 1);广东省重点科技攻关项目(批准号 :A30 2 0 2 0 2 0 2 )资助

摘　　要：3-羟基丁酸 -co-3-羟基戊酸共聚物 (PHBV) /生物活性玻璃 (SGBG)是一种用于骨和软骨组织工程支架的新型多孔复合材料 ,本文探讨了 PHBV/ SGBG在模拟生理溶液中的一系列化学反应 ,以及多孔材料在模拟生理溶液中浸泡后的成分和结构变化 .研究结果表明 ,在 SBF溶液中浸泡后 ,SGBG与 SBF溶液的离子交换反应和 PHBV的降解反应使 SBF溶液的离子浓度发生变化 ,并在 PHBV/ SGBG表面形成了结晶态类骨碳酸羟基磷灰石 .A new kind of porous composites prepared from poly(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV) and sol gel bioactive glass(SGBG) are used for born tissue engineering scaffolds. In this work, the chemical reaction and in vitro degradation of PHBV/SGBG porous materials was assessed in simulated body fluid(SBF). The changes in components and structures of the porous materials were investigated before and after immersion in SBF. It was found that the ion concentrations of SBF changed with immersing time because of ion exchange reaction and degradation reaction of PHBV/ SGBG in SBF solution. FTIR and XRD analysis indicated that hydroxyl carbonate apatite(HCA) had formed on the surface of PHBV/SGBG after the porous scaffold was exposed to SBF solution for 12 h.

关 键 词：PHBV/Sol-gelBioglass 多孔材料 模拟生理溶液 化学反应 3-羟基丁酸-co-3-羟基戊酸共聚物 生物活性玻璃 软骨组织 生物材料 

分 类 号：R318.08[医药卫生—生物医学工程]