天香丹颗粒对冠心病心绞痛患者血清中T-SOD、GSH-Px、MDA、LD的影响  

The Effect of Tianxiangdan Granule on T-SOD, GSH-Px, MDA, LD in Serum of Angina of Coronary Heart Disease Patients

作　　者：殷建明 朱江丽[2] 刘琴[2] 安冬青[2] 

机构地区：[1]新疆独山子石化医院,独山子833600 [2]新疆医科大学附属中医医院

出　　处：《中国中医药信息杂志》2003年第7期13-15,共3页Chinese Journal of Information on Traditional Chinese Medicine

摘　　要：目的:研究天香丹颗粒对冠心病心绞痛患者血清中T-SOD、GSH-Px、MDA、LD的影响。方法:62例冠心病心绞痛气虚血瘀、痰瘀交阻证患者随机分为两组,治疗组30例,对照组32例。服用天香丹颗粒1个疗程(4周)后,观察患者临床症状以及血清中超氧化物歧化酶(T-SOD)、谷胱甘肽过氧化物酶(GSH-Px)活力和丙二醛(MDA)、乳酸(LD)含量的变化。结果:①两组患者均能明显改善临床症状。天香丹组对胸闷、体倦乏力、舌黯瘀斑、脉滑症状的改善明显优于心可舒组,两者存在显著差异。②两组患者治疗后血清中T-SOD、GSH-Px活力均明显升高,MDA、LD含量明显降低。天香丹组降低MDA水平优于心可舒组。③天香丹组两证型治疗后血清中T-SOD、GSH-Px活力明显升高,MDA、LD含量明显下降,均有显著差异。两证型间比较无显著差异。结论:天香丹颗粒具有阻止自由基的损害和抑制乳酸形成的作用。这可能是其治疗冠心病心绞痛的机理之一。Objective: To study the influence on T-SOD, GSH-Px, MDA, LD level in serum therapy with Tianxiangdan granule on angina of coronary heart disease patients. Methods: 62 patients were randomly divided into treated group (n=30) and control group (n=32). Patients take this medicine one period of treatment (four weeks). Observe the variety of T-SOD, GSH-Px, MDA, LD level in serum. Results: After therapy, the two group can all improve the clinic symptoms, and the treated group were superior to the control group. The energy of T-SOD, GSH-Px increased significantly, the level of MDA, LD falled significantly in serum. Conclusion: Tianxiangdan granule can prevent the damages of free radical, prevent the forms of lactic acid. Perhaps this is one of the mechanism for Tianxiangdan granule on therapy.

关 键 词：天香丹颗粒 冠心病 心绞痛 血清 T-SOD GSH-PX MDA LD 超氧化物歧化酶 谷胱甘肽过氧化物酶 丙二醛 乳酸 

分 类 号：R259.414[医药卫生—中西医结合]