不同剂量紫草醇提取物对表皮细胞过度增殖的实验研究  

The inhibit effect of different doses of alcohol extracts from ZiCao on psoriatic epidermic hyperproliferation

作　　者：刘梅青[1] 

机构地区：[1]太原市中心医院集团,山西太原030009

出　　处：《临床医药实践》2003年第7期485-487,共3页Proceeding of Clinical Medicine

摘　　要：目的 :研究不同剂量紫草醇提取物对实验性银屑病表皮细胞过度增殖的抑制作用。方法 :以不同剂量紫草醇提取物给雌激素周期模型的小鼠灌胃 ,计数阴道上皮基底细胞的有丝分裂指数。结果 :各剂量组均有明显作用 ( P<0 .0 1) ,以 7.5 g/ kg剂量组作用显著 ,剂量与作用有直线相关性 ( r=0 .666)。结论 :各剂量组对银屑病样表皮过度增殖均有较好的作用 ,以 7.5 g/ kg剂量作用最佳 。Objective:To explore the effect of different doses of alcohol extracts from ZiCao on psoriatic epidermic hyperproliferation.Methods:The model mice produced pathologically from estrogen-induced vagina epidermis were orally administrated with different doses of alcohol extracts.The mitosis index of base cells were examined by LM.Results:The different doses all have obvious effects and have a linear dose-effect correlation.Conclution:The alcohol extracts of ZiCao have good effect on psoriatic epidermic hyperproliferation with different doses,and have a positive dose-effect correlation,the effect of 7.5 g/kg dose is better.

关 键 词：紫草醇提取物 表皮细胞 过度增殖 实验研究 

分 类 号：R284.2[医药卫生—中药学] R285.5[医药卫生—中医学]