Synthesis and Chiral Separation of Dinucleotide(TpAZT) Phosphoramidates  

作　　者：ChangXueLIN HuaFU GuangZhongTU YuFenZHAO 

机构地区：[1]KeyLaboratoryofBioorganicPhosphorusChemistry,MinistryofEducation,DepartmentofChemistry,SchoolofLifeSciencesandEngineering.TsinghuaUniversity.Beijing100084 [2]BeijingInstituteofMicrochemistry,Beijing100091

出　　处：《Chinese Chemical Letters》2003年第8期779-782,共4页中国化学快报（英文版）

基　　金：The authors would like to thank the financial supports from the National Natural Science Foundation of China(No.29902003,20132020 and 20175026),the Ministry of Science and Technology,the Chinese Ministry of Education and Tsinghua University.

摘　　要：Dinucleotide (TpAZT) phosphoramidates were synthesized by Todd reaction of dinucleoside H-phosphonates and amino acid methyl esters, and their diastereomers (Rp and Sp) were separated by crystallization, and the results showed that natural and cheap methyl esters of alanine and phenylalanine can be used for large-scale synthesis of dinucleotide analogs.

关 键 词：Dinucleotide phosphoramidate chiral auxiliary chiral separation. 

分 类 号：R512.91[医药卫生—内科学] R978.7[医药卫生—临床医学]