体外受精与胚胎移植治疗不孕症290个周期临床分析  

A Clinical Analysis of 290 Cycles for Treatment of Infertility by Vitro Fertilization and Embryo Transfer

作　　者：郑仁瑞[1] 任建枝[1] 李萍[1] 邱慧玲[1] 黄菲[1] 沙爱国[1] 周友泉[1] 

机构地区：[1]解放军第一七四医院生殖医学中心,福建厦门361003

出　　处：《实用临床医学（江西）》2003年第4期77-80,共4页Practical Clinical Medicine

摘　　要：目的 :分析体外受精与胚胎移植 (IVF ET)治疗不孕症 2 90个周期的效果。方法 :采用GnRHa/FSH/hCG和GnRHa/FSH/hMG/hCG两种超促排卵方案 ,对 2 5 2对不孕夫妇共进行了 2 90个周期常规IVF、冻融胚胎或卵胞浆内单精子显微注射 (ICSI)及胚胎移植 (ET)治疗。结果 :合计 2 90个周期共获临床妊娠 10 5例 ,周期妊娠率为36 .2 %。流产 9例 ,异位妊娠 11例 ,已分娩 6 5例 ,获新生儿 91个 ,另 2 0例继续妊娠。按女性年龄 <30岁、30～ 34岁、35～ 39岁、≥ 4 0岁分为 4个年龄组 ,4组的周期妊娠率依次为 4 7.0 %、34.1%、2 5 .5 %、0 ,有统计学差异 (P <0 .0 5 )。结论 :不孕夫妇用常规IVF、冻融胚胎移植或ICSI后均能获得较好的妊娠效果。Objective:To review the results of 290 cycles In Vitro Fertilization and Embryo Transfer(IVF ET).Methods:Total 252 couples(290 cycles)were accepted for treatment by conventional IVF,frozen thawed embryo or ICSI.The protocol of controlled superovulation was GnRHa/FSH/hMG/hCG or GnRHa/FSH/hCG.Results:There were three groups:conventional IVF,frozen thawed embryo and ICSI groups. Two hundred and ninety cycles were divided into four groups by female age(<30,30～34, 35～39,≥40 years old),respectively.The total clinical pregnancies were 105 cases and clinical pregnancy rate of per ET cycles was 36.2% from 290 cycles.From a total of 105 pregnancies,9 patients had spontaneous abortion,11 had ectopic pregnancy,65 had delivery of 91 liveborn babies and 20 were ongoing pregnancy.The clinical pregnancy rate was 47.0%,34.1%,25.5% and 0.0%,respectively.There was a significant difference( P <0.05).Conclusion:Couples with female or male infertility have good pregnancy rates after conventional IVF, frozen thawed embryo or ICSI,and the clinical pregnancy rate of per cycle is closely related with the female age.

关 键 词：体外受精 胚胎移植 冷冻胚胎 卵胞浆内单精子注射 

分 类 号：R321.2[医药卫生—人体解剖和组织胚胎学]