海藻酸锌络合物血液灌流吸附尿素的实验研究  

EXPERIMENTAL STUDY ON HEMOPERFUSION IN REMOVING UREA WITH ALGINATE-Zn COMPLEX

作　　者：于美丽[1] 宋继昌[1] 孙铭[1] 许有华[1] 郑惠英[1] 吕文岚[1] 付丽[1] 

机构地区：[1]天津市第三中心医院,天津300170

出　　处：《中国生物医学工程学报》2003年第4期343-349,共7页Chinese Journal of Biomedical Engineering

基　　金：天津市卫生局科学基金资助项目 ( 993 60 791)

摘　　要：首次采用海藻酸锌络合物配位吸附尿素分子 ,研究了这类络合物在不同条件下对尿素的吸附性能。用纯种大耳白兔作为实验动物 ,建立肾衰动物模型。海藻酸锌络合物为吸附剂对动物模型进行血液灌流实验 ,观察该吸附剂血液灌流清除体内尿素的功效 ,以及对肝功能、肾功能等临床生化指标的影响。在模拟人体生理介质的水溶液中对尿素吸附率达 74 .6 5± 4 .71%。对血液中尿素的吸附率达 6 5 .2 5± 4 .33%。经动物血液灌流对血液中Bun、Cr的清除率达 6 0 %以上。Alginate-Zn complex beads were prepared for removal of urea. The effect on urea sorption capacity was discussed in detail. A rabbit model of renal failure was established, and then an experimental hemoperfusion using Aliginate-Zn complex was performed. The adsorption efficiency of the complexes was determined to be 74.64±4.71% in a buffer of Na2H 2PO4-NaH2PO4 (pH = 7.4) and 65.25 ± 4.33% in blood. The effect of hemoperfusion in removing urea in blood and the influence of Alginate-Zn complex on liver and kidney functions were observed.

关 键 词：尿素吸附剂 海藻酸锌络合物 血液灌流 尿素 

分 类 号：R318.08[医药卫生—生物医学工程]