NMDA受体参与小鼠的前额扣带回的神经突触传递(英文)  

NMDA receptors contribute to synaptic transmission in anterior cingulate cortex of adult mice

作　　者：Jason LIAUW 王过渡[1] 卓敏[1] 

机构地区：[1]华盛顿大学医学院麻醉系

出　　处：《生理学报》2003年第4期373-380,共8页Acta Physiologica Sinica

基　　金：Research supported by grants from NINDS (NS38680), NIDA (DA10833), the McDonnell Center for Higher Brain Function at Washington University;the EJLB-CIHR Michael Smith Chair in Neuroscienees and Mental Health.

摘　　要：谷氨酸性突触是哺乳动物神经系统的主要兴奋性突触。在正常条件下,大多数的突触反应是由谷氨酸的AMPA受体传递的。NMDA受体在静息电位下为镁离子抑制。在被激活时,NMDA受体主要参与突触的可塑性变化。但是,许多NMDA受体拮抗剂在全身或局部注射时能产生行为效应,提示NMDA受体可能参与静息状态的生理功能。此文中,我们在离体的前额扣带回脑片上进行电生理记录,发现NMDA受体参与前额扣带回的突触传递。在重复刺激或近于生理性温度时,NMDA受体传递的反应更为明显。本文直接显示了NMDA受体参与前额扣带回的突触传递,并提示NMDA受体在前额扣带回中起着调节神经元兴奋的重要作用。Glutamatergic synapses are common excitatory chemical connections in mammalian central nervous system. At these synapses, most of baseline synaptic transmission is mediated by glutamate AMPA receptors. NMDA receptors that are sensitive to voltage-dependent magnesium blockade selectively contribute to activity-dependent synaptic plasticity. However, inhibition of NMDA receptors by systemic or local administration of NMDA receptor antagonists produced significant effects on different physiological functions that are not believed to depend on NMDA receptor related synaptic plasticity. Here we show that NMDA receptors contribute to synaptic responses in the anterior cingulate cortex (ACC), a region important for cognitive and other brain functions. The contribution of NMDA receptors became more prominent when synapses are stimulated at higher frequencies. Furthermore, at temperatures more close to physiological brain temperatures, more NMDA receptor mediated responses were recorded as compared to the room temperature. These data suggest a new function for NMDA receptors in the ACC as important postsynaptic receptors involved in synaptic transmission, in particular when cells are firing at high frequencies.

关 键 词：谷氨酸 前额扣带回 痛觉 小鼠 

分 类 号：Q421[生物学—神经生物学]