抑毒调平液对慢性乙型肝炎患者疗效的观察  

OBSERVATION OF EFFICACY OF YIDUTIAOPINGYE ON PATIE- NTS WITH CHRONIC HEPATITIS B VIRUS INFECTION

作　　者：刘玉华[1] 唐坤华[2] 余光开[2] 邓存良[2] 李莉 

机构地区：[1]中南大学湘雅二院内分泌所,湖南长沙410011 [2]泸州医学院附属医院感染科 [3]四川省空军医院

出　　处：《泸州医学院学报》2003年第3期214-216,共3页Journal of Luzhou Medical College

摘　　要：目的 :评价中草药制剂抑毒调平液改善肝功能和抗乙肝病毒作用。方法 :60例慢性乙型肝炎 (中度 )患者按随机双盲原则分为治疗组、对照组 (每组 30例 ) ,分别口服抑毒调平液和安慰剂。收集治疗前、治疗后及停药 3月末空腹血清标本 ,用酶联免疫吸附法 (ELISA)检测乙肝病毒标志物 (HBV -M) :HBsAg、抗HBs、HBeAg、抗HBe、抗HBc ;多聚酶链反应 (PCR)结合琼脂糖凝胶电泳法进行HBVDNA定性检测。结果 :治疗组和对照组在改善肝功和HBeAg、HBVDNA阴转率方面均有显著差异 (P <0 .0 5)。结论 :抑毒调平液能显著改善慢性乙型肝炎病毒 (HBV)感染者的肝功能 ,有确切的抗HBV作用 ;Objective:To evaluate the efficacy of herb- preparation YiDuTiaoPingYe(YDTPY) on patients infected with hepatitis B virus(HBV) . Method:60 patients infected with HBV were randomized into two groups, receiving either YDTPY (T group,n=30) or Placebo(C group,n=30). Before and after treatment as well as 3 months after withdrawal, HBeAg was measured with enzyme-linked immunosorbent assay(ELISA) and HBV DNA with polymerase chain reaction(PCR) binding agarose gel eletrophoresis.Results: Within the observing period, HBeAg and HBV DNA negative convertion rate maintained a sustained increase in T group compared with C group(P<0.05). ALT,AST,TBIL decreased (P<0.05). Conclusion: YDTPY has a long-sustained immunoregulation, antiviral effects and the improving liver function as well.

关 键 词：乙型肝炎 抑毒调平液 肝功能 HBEAG HBV DNA阴转率 

分 类 号：R512.62[医药卫生—内科学]