用于骨组织工程的羟基丁酸-戊酸共聚物/生物活性玻璃复合多孔支架材料  

RESEARCH ON POROUS BONE-TISSUE ENGINEERING SCAFFOLDS MADE FROM POLYHYDROXYALKANOATE/BIOACTIVE GLASS COMPOSITES

作　　者：任耀彬[1] 郑裕东[1] 王迎军[1] 陈晓峰[1] 吴刚[1] 

机构地区：[1]华南理工大学材料学院,广东广州510640

出　　处：《高分子材料科学与工程》2003年第4期196-199,共4页Polymer Materials Science & Engineering

基　　金：国家自然科学基金 ( 5 993 2 0 5 0 );广东省自然科学基金 ( 990 62 1);广东省十五重大专项 ( A3 0 2 0 2 0 2 0 2 )资助项目

摘　　要：研究了用于骨组织工程的复合型羟基丁酸 -戊酸共聚物 /溶胶 -凝胶生物活性玻璃多孔支架材料 ,采用溶液浇注沥滤法制备了任意形状的三维连通多孔结构支架 ,并进行三维结构表征和显微形貌观察 ;通过对成型条件的调节 ,可控制支架的孔径和孔隙率 ;在模拟生理体液中进行复合支架材料的生物活性测试。研究表明 ,通过控制致孔剂用量、尺寸大小和分散 ,得到的支架材料呈三维连通开孔结构 ,且孔隙分布均匀、孔隙率达 90 %以上 ;扫描电镜观察结果显示 ,羟基丁酸 -戊酸共聚物与生物活性玻璃良好相容 ,后者粘附在支架孔壁上 ;支架在模拟生理体液中浸泡后发现生物活性玻璃表面有羟基碳酸磷灰石多晶体生成 ,表明复合支架仍保持了In this work, a porous polyhydroxyalkanoate/sol-gel bioactive glass bone tissue engineering scaffold was prepared via solution-casting and porogen particular-leaching techniques. Porosity of the scaffold and effect of the simulated body fluid (SBF) on the structure and properties of the scaffold were tested and investigated by weight loss and FT-IR tests. The micro-morphology of the porous scaffold′s surface and cross section were observed using scanning electron microscope. It was found that the porosity of the porous scaffold increased with ratio of both porogen and bioglass, independent of porogen particle size. Pores inside the scaffold were interconnected in three-dimensions, with the sol-gel bioactive glass particles embeded in the pore walls. SEM observation revealed that the bioglass particles in the porous composite had reacted significantly with SBF solution. FT-IR and SEM analysis indicated that hydroxyl carbonate apatite (HCA) had formed on the surface of the sol-gel bioactive glass after the porous scaffold was exposed to SBF solution for 5 d.

关 键 词：骨组织工程 羟基丁酸-戊酸共聚物 生物活性玻璃 复合多孔支架材料 组织工程支架 

分 类 号：TB39[一般工业技术—材料科学与工程] R318.08[医药卫生—生物医学工程]