盐酸安非他酮的合成研究  

Study on Synthesis of the Amfebutamone Hydrochloride

作　　者：夏闽[1] 徐宝峰[1] 

机构地区：[1]临沂师范学院化学与环境科学系,山东临沂276005

出　　处：《山东化工》2003年第3期3-5,共3页Shandong Chemical Industry

摘　　要：盐酸安非他酮为一种抗抑郁药物。以间氯苯基乙酮为原料 ,经溴代 ,N -烃基化反应得盐酸安非他酮。在溴化反应中采用新型溴试剂 ,避免了直接溴代 ,溴代产率提高至 85 %。在N -烃基化反应中使用聚乙二醇作相转移剂 ,得到高产率产物 ,结构经IR ,1Amfebutamone hydrochloride is an antidepressant.1-(3-chlorophenyl)-1-propanone takes for raw material.After through brominating,N-alkylation,the amfebutamone hydrochloride was obtained.A new bromizating agent was used in the brominating reaction.Immediate brominating was averted.The yield was over 85%.Polyethylene glycol(PEG)took for phase-transfer catalyst(PTC) in the N-alkylation reaction which good yields.The structures of the products were determined by IR, 1HNMR and elemental analysis.

关 键 词：盐酸安非他酮 溴试剂 相转移催化 合成 

分 类 号：TQ463.4[化学工程—制药化工] R971.43[医药卫生—药品]