抵当汤改良方对实验性动脉粥样硬化家兔主动脉脂质斑块部泡沫细胞凋亡的影响  

Effects of Improving Prescription of Didang-tang on the Apoptosis of Foam Cell of Aorta Lipid Plaque of Experimental Atherosclerosis Rabbits

作　　者：黄河清[1] 刘培庆[1] 黑子清[2] 

机构地区：[1]中山大学药学院,广州510080 [2]中山大学附属第一医院

出　　处：《中国中医药信息杂志》2003年第6期29-31,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：广东省自然科学基金(№.001399)

摘　　要：目的:观察抵当汤改良方对实验性动脉粥样硬化(AS)家兔主动脉脂质斑块部泡沫细胞凋亡的影响。方法:运用薄层扫描法检测主动脉脂质斑块部细胞凋亡第二信使转导物神经酰胺的含量;运用TUNEL法检测主动脉脂质斑块部泡沫细胞的凋亡,计算凋亡指数。结果:抵当汤改良方能有效减少主动脉脂质斑块部神经酰胺的含量,抑制其泡沫细胞的凋亡。结论:抵当汤改良方抗实验性动脉粥样硬化的作用与减少主动脉脂质斑块部的泡沫细胞凋亡有关。Objective: To observe the effects of improving prescription of Didang-tang (IPDT) on the apoptosis of foam cell of aorta lipid plaque of experimental atherosclerosis(AS) rabbits. Methods: The ceramide-secondly messenger of apoptosis of aorta lipid plaque with thin layer scannig; the apoptosis of foam cell of aorta lipid plaque with TUNEL method, and counting the apoptosis index. Results : IPDT could effectivly reduce the ceramide content of aorta lipid plaque, and control the apoptosis of foam cell. Conclusion: IPDT on experimental AS related to decrease of the apoptosis of foam cell of aorta lipid plaque.

关 键 词：抵当汤改良方 实验 动脉粥样硬化 家兔 泡沫细胞 细胞凋亡 神经酰胺 高脂血症 

分 类 号：R259.43[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]