贵州冬凌草中的对映-贝壳杉烷二萜化合物  

ent-Kaurane Diterpenoids from Isodon rubescens Collected in Guizhou Province

作　　者：韩全斌[1] 赵勤实[1] 黎胜红[1] 彭丽艳[1] 孙汉董[1] 

机构地区：[1]中国科学院昆明植物研究所植物化学和西部植物资源持续利用国家重点实验室,昆明650204

出　　处：《化学学报》2003年第7期1077-1082,共6页Acta Chimica Sinica

摘　　要：从贵州产冬凌草[Isodon rubescens(Hemsl.)Hara]中分离得到12个6,7-断裂-7,20-内酯-对映-贝壳杉烷二萜化合物,经波谱分析鉴定了它们的结构,其中有7个新化合物,分别命名为贵州冬凌草乙素～辛素(guidongnins B～H,1～7),以及卢氏冬凌草甲素(8)、卢氏冬凌草乙素(9)、贵州冬凌草素(10)、狭叶香茶菜素(angustifolin,11)和6-表狭叶香茶菜素(6-epiangustifolin,12)等5个已知化合物.另外,将作者原命名的贵州冬凌草素(guidongnin,10)更名为贵州冬凌草甲素(guidognin A,10),并利用二维核磁共振波谱技术修订了卢氏冬凌草乙素的结构.Twelve 6, 7-seco-7, 20-olide-ent-kaurane diterpenoids, including seven new compounds named guidongnins B similar to H (1 similar to 7) and five known ones identified as ludongnin A (8), ludongnin B (9), guidongnin (10), angustifolin (11) and 6-epiangustifolin (12), were isolated from Isodon rubescens collected in Guizhou Province. On the basis of spectroscopic evidences, the new compounds were elucidated as 16 ( R)-methyl-6, 7-seco-6, 19; 7, 20-diolide-ent-kaur-15-one (1), 16 (R)-methyl-11alpha-hydroxy-6, 7-seco-6, 19; 7,20-diolide-ent-kaur-15-one (2), 16 (S)-hydroxymethyl-11alpha-hydroxy-6,7-seco-6,19;7,20-diolide-ent-kaur-15-one (3), 16(R)-methyl-6alpha-hydroxy-6, 7-seco-6,19-epoxy-7, 20-olide-ent-kaur-15-one (4), 16 (R)-methyl-6beta-hydroxy-6, 7-seco-6, 19-epoxy-7,20-olideent-kaur-15-one (5), 6beta,15beta-dihydroxy-6,7-seco-6,19-epoxy-7,20-olide-enx-kaur-16-ene (6) and 16(R)-methyl-19beta-oxymethyl-6,7-seco-6,19-epoxy-7,20-olide-ent-kaur-15-one (7), respectively. The structure of ludongnin B was revised by 2D-NMR spectra and the name of guidongnin (10) was renamed guidongnin A (10).

关 键 词：贵州 冬凌草 对映-贝壳杉烷二萜化合物 冬凌草素 狭叶香茶菜素 6-表狭叶香茶菜素 卢氏冬凌草乙素 植物药 

分 类 号：TQ461[化学工程—制药化工]