克狼灵煎剂对GVHR狼疮样小鼠作用的实验研究  

An Experiment Investigation on Effect of KeLangLing Decoction to GVHR SLE-like Mice Model

作　　者：贺学林[1] 李夏玉[1] 温成平 范永升 

机构地区：[1]浙江大学医学院附属第一医院肾脏病中心,浙江杭州310003 [2]浙江中医学院,浙江杭州310012

出　　处：《中国中医基础医学杂志》2003年第6期27-29,35,共4页JOURNAL OF BASIC CHINESE MEDICINE

摘　　要：目的 :观察克狼灵对系统性红斑狼疮动物模型的效果并探讨其作用机理。方法 :采用了诱导型移植物抗宿主反应 (GVHR)狼疮样小鼠模型 ,设立对照组 ,进行了 14周的系统观察。结果 :克狼灵能降低小鼠模型的自身抗体和尿蛋白水平 ,改善其肾脏病理变化 ,对脾指数无明显影响。结论 :克狠灵对SLE的作用机制与强的松不同 ,可能与神经 内分泌 免疫网络系统有关 ,值得进一步深入系统研究。Objective:To observe the effect of KeLangLing decoction to SLE-like mice model and study its mechanisms.Methods:Induced gr aft-versus-host reaction (GVHR) SLE-like mice were used as models and were ob served 14 weeks in different control groups.Results:The results showed KeLan gLing decoction reduced the level of auto-antibody and urine protein,ameliora te d model mice kidney pathological changes and had no effect on spleen index.Concl usions:The mechanisms of KeLangLing on SLE were different from meticorten,pr obably had relation with nerve-endocrine-immunological network and needed deep and systemic research.

关 键 词：克狼灵煎剂 GVHR 狼疮样小鼠 实验 系统性红斑狼疮 移植物抗宿主反应 中医药疗法 克狼灵 

分 类 号：R259.932.41[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]