电针“中膂俞”抑制膀胱活动亢进的实验研究  

Effects of Electroacupuncture of "Zhonglushu" on Experimental Hyperactivity of the Bladder in the Rat

作　　者：王翔宇[1] 郑蕙田[2] 蔡定芳[1] 

机构地区：[1]复旦大学附属中山医院中医科,上海200032 [2]上海市针灸经络研究所,上海200030

出　　处：《针刺研究》2003年第2期119-123,共5页Acupuncture Research

摘　　要：目的 :探讨电针“中膂俞”对L 多巴诱发膀胱活动亢进的尿动力学影响。方法 :以L 多巴诱发的膀胱活动亢进为动物模型 ,在动物清醒和自由活动的状态下 ,应用连续膀胱测压技术动态观察电针“中膂俞”对排尿过程中尿动力学参数的影响。结果 :电针“中膂俞”可减少排尿频率 ,降低膀胱基础压 ,升高膀胱最大充盈压和排尿压 ,增加排尿量。结论 :电针“中膂俞”对LObjective: To observe the effects of electroacupuncture (EA) of 'Zhonglushu' (BL 29) on urodynamics in L-dopa induced bladder hyperactivity. Methods: 72 SD rats were randomly and evenly divided into normal group, model group and EA group. Overactivity model of the bladder was established by intraperitoneal injection of 5% benserazid (2.5 mL/kg) and 1% L-dopa(2.5 mL/kg). Before each experiment, a median incision of the bladder was performed for intubation to measure various parameters of urodynamics. 3 days later, continuous cystometrogram was recorded under conscious state and without any restraint for observing the effects of EA on L-dopa-induced bladder overactivity. For animals of normal control group, normal saline (2.5 mL/kg) was injected intraperitoneally, and those of model and EA groups were injected with benserazid and L-dopa. Bilateral 'Zhonglushu' (BL 29) were punctured and stimulated with an EA therapeutic apparatus (5 Hz, 4～6 V and 30 min). Results: Before treatment, the basic pressure (Pbas), maximal filling pressure (Pmax), micturition pressure (Pm), micturition circle (MC), time of micturition (Tm), number of micturition (Nm) and volume of micturition (Vm) had no apparent differences among the 3 groups (P>0.05). Half an hour and an hour after treatment, compared with normal control group, Nm and Pbas of model and EA groups increased significantly (P<0.05), while Pmax, Pm and Vm of the latter two groups decreased considerably (P<0.05). In comparison with model group, one hour after treatment, Nm and Pbas of EA group were markedly lower, whereas Pmax, Pm and Vm were strikingly higher (P< 0.05). It indicates that EA can lessen micturion frequency and bladder basal pressure, and increase micturition pressure and micturition volume in bladder hyperactivity rats. Conclusion: EA of 'Zhonglushu' can inhibit the hyperactivity of the bladder effectively.

关 键 词：膀胱活动亢进 电针 中膂俞 尿动力学参数 L-多巴 动物实验 

分 类 号：R277.545[医药卫生—中医学] R245.97