六种与HLA相关联疾病的易感基因研究进展  

Genome-wide scanning for susceptibility genes in researches on six HLA-associated diseases

作　　者：顾鸣敏[1] 王铸钢[1] 黄薇 范丽安[3] 

机构地区：[1]上海第二医科大学医学遗传学教研室,200025 [2]国家人类基因组南方研究中心 [3]上海第二医科大学免疫学教研室暨上海市免疫学研究所,200025

出　　处：《中华医学遗传学杂志》2003年第4期336-341,共6页Chinese Journal of Medical Genetics

基　　金：国家自然科学基金 (39970 742 );国家杰出青年科学基金(3992 50 2 3);国家自然科学基金重大项目 (3999342 0 )~~

摘　　要：选择 6种与人类白细胞抗原 (human leucocytic antigen,HL A)相关联疾病 :强直性脊柱炎、类风湿性关节炎、多发性硬化症、系统性红斑狼疮、1型糖尿病和银屑病 ,比较分析这些疾病在全基因组扫描寻找易感基因方面的研究现状及特点 ,并对相关研究中存在的问题及可能的对策提出见解。Six human leucocytic antigen (HLA)-associated diseases, including ankylosing spondylitis, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, type 1 diabetes mellitus and psoriasis, were selected as objects of this review. The characteristics of these diseases in whole-genome scans on susceptibility genes or loci undertaken to date were analyzed and compared. Meanwhile, the potential proposals for dealing with the existing problems were put forward.

关 键 词：人类白细胞抗原相关联疾病 易感基因 研究进展 强直性脊柱炎 类风湿性关节炎 多发性硬化症 

分 类 号：R596.1[医药卫生—内科学]