褶合曲线分析法同时测定小儿复方苯巴比妥片中四组分的含量  

Application of convolution curve method for simultaneous determination of four components in the compound children's phenobarbital tablet

作　　者：高金波[1] 丁立新[1] 侯巍[1] 张羽男[1] 吕宁 

机构地区：[1]佳木斯大学化学与药学院,黑龙江佳木斯154007 [2]齐齐哈尔铁路中心医院,黑龙江齐齐哈尔161000

出　　处：《药学实践杂志》2003年第4期214-216,共3页Journal of Pharmaceutical Practice

摘　　要：目的:不经分离同时测定小儿复方苯巴比妥片中四组分的含量。方法:以褶合光谱为基础,结合当前最优秀的数值计算法——偏最小二乘法(PLS法)利用计算机信息处理技术的褶合曲线分析法。结果:小儿复方苯巴比妥片中阿司匹林、非那西丁、咖啡因和苯巴比妥四组分的平均回收率及相对标准偏差(RSD)分别为99.75,0.92％;100.47,0.56％;99.82,1.12％;100.08,0.86％。结论:该方法可以用于小儿复方苯巴比妥片剂的质量监控。OBJECTIVE: Without any separation, simultaneous determination of four main components in the compound children's phenobarbital tablet. METHODS: Based on convolution spectrometry with the excellent cacu-lation method-PLS method used convolution spectrometry of computer information process technology. RESULTS: Components of compound children's phenobarbital tablet are aspirin, phenacetin, caffine and phenobarbital . Their average recoveries and RSD were 99. 75 ,0. 92% : 100. 47 ,0. 56% : 99. 82,1. 12% : 100. 08 ,0. 86% . CONCLUSION: The method is used for qualitative control of compound children's phenobarbital tablet.

关 键 词：小儿复方苯巴比妥片 组分 含量测定 褶合曲线分析法 数值计算法 

分 类 号：R985[医药卫生—药品] R927.2[医药卫生—药学]