联合用药组方治疗原发性高血压远期疗效  

Comparison of long-term efficacy of two combination of prescriptions in treatment of essential hypertension

作　　者：王静[1] 

机构地区：[1]内蒙古自治区医院,内蒙古呼和浩特010017

出　　处：《心脏杂志》2003年第4期328-330,共3页Chinese Heart Journal

摘　　要：目的 :观察两个联合用药组方治疗原发性高血压的远期临床效果。方法 :高血压患者 10 6例 ,随机分成长期用药组和对照组各 5 3例。长期用药组又随机分为甲、乙两组 ,其中甲组 2 5例 ,服用组方 1(双氢克尿噻和硝苯地平片各 7.5 mg) ,乙组 2 8例 ,服用组方 2 (尼群地平片 3mg,依那普利片 1.5 m g和吲哒帕胺片 0 .5 mg) ,对照组患者自行或间断服药。结果 :长期用药组与对照组相比能显著地降低高血压患者的收缩压和舒张压 (P<0 .0 1) ,甲组和乙组降压幅度无显著性差异 (P>0 .0 5 ) ,对心率均无显著性影响 (P>0 .0 5 ) ,副作用均较轻微。结论 :两个联合用药组方治疗原发性高血压远期疗效稳定可靠 ,而且可明显减少心脑血管事件的发生率。AIM:To observe the long-term clinical efficacy of two combinations of pressriptions in treatment of essential hypertension.METHODS:106 cases of essential hypertension patients were randomly divided into the long-term prescription and control groups,each 53 subjects. The long-term prescription group was randomly divided into two groups,in which the first group(25 cases) intake combination 1(Dihydrochlorothiazide 7.5 mg,Nifedipine 7.5 mg);the second group(28 cases) intake combination 2(Indapamide 0.5 mg,Nitrendipine 3 mg,Enalapril 1.5 mg). The subjects in the control group interruptedly intake medicine without doctors' guidance. RESULTS:The systolic pressure and diastolic pressure drop dramatically compared with those of the control group members(P<0.01). Between the first and second groups,there is no striking difference in the range of the decline of blood pressure (P>0.05),and their cardiac rates are not affected (P>0.05);side effects of the medicine used by the two group subjects are slight. CONCLUSION:The long-term efficacy of two combinations of prescriptions are steady and reliable in treatment of essential hypertension and the incidence of the heart and brain artery events drop dramatically.

关 键 词：高血压 原发性 联合用药组方 长期用药 

分 类 号：R544.1[医药卫生—心血管疾病]