甲状旁腺激素测定在慢性肾功能衰竭中的临床意义  

The determination of parathyroid hormone in the chronic renal failure and its clinical significances

作　　者：钱宇锋[1] 蔡卫民[1] 

机构地区：[1]南京军区南京总医院药学部，江苏南京210002

出　　处：《医学研究生学报》2003年第7期536-538,542,共4页Journal of Medical Postgraduates

基　　金：国家自然科学基金资助 (批准号 :3 0 2 715 2 6) ;江苏省自然科学基金资助 (批准号 :BK2 0 0 2 0 97)

摘　　要：继发性甲状旁腺功能亢进症 (SHPT)是慢性肾功能衰竭 (CRF)及终末期肾病 (ESRD)患者常见的并发症之一 ,并随原发病进展而逐渐加重 ,而且甲状旁腺激素 (PTH)是肾病进展的指标之一。作者从PTH的生理意义、在CRF或ESRD时PTH升高的原因及其临床意义、临床测定PTH浓度的方法、PTH升高与基因 (CYP2D6、GSTT1及GSTM1 )多态性的关系等方面 。The secondary hyperparathyroidism is one of the complications of chronic renal failure (CRF) and end stage renal failure (ESRD), and becomes more serious with the development of the primary disease. Parathyroid hormone (PTH) is considered as one of the biomarks of the development of renal failure. The purpose of this article will expound the physiological effects of the PTH, the causes and clinical significances of PTH rising in CRF and ESRD patients, the determination of PTH level, and the relationships between the increase of PTH and the polymorphism of CYP2D6, GSTT1,GSTM1.

关 键 词：甲状旁腺激素 慢性肾功能衰竭 终末期肾病 基因多态性 双位点免疫放射测定法 

分 类 号：Q573[生物学—生物化学]