白介素1β基因多态性与苯那普利疗效的相关性研究  

Study on Association Between Interleukin-1 β Gene Polymorphism and Benazepril Response

作　　者：黄帼[1] 应剑[1] 洪宗元[1] 凌代俊[1] 李栋[1] 余运贤[1] 江承设[1] 黄爱群[1] 彭少杰[2] 吴涤[2] 刘兢[1] 张学军[3] 徐希平[1] 

机构地区：[1]中国科学技术大学生命科学学院,安徽合肥230027 [2]安徽省生物医学研究所,安徽合肥230032 [3]安徽医科大学,安徽合肥230032

出　　处：《中国科学技术大学学报》2003年第4期491-499,共9页JUSTC

摘　　要：为了研究白介素1β基因 511多态位点与血管紧张素1转化酶抑制剂—苯那普利疗效的相关性,对中国安徽省霍邱(n=594)和岳西(n=352)两地区患有原发性高血压病患者用苯那普利连续治疗15天,其间测量患者的血压和收集患者血样.用聚合链反应—限制性片段长度多态性(PCR RFLP)方法对所有患者的白介素1β( 511)多态位点进行了基因型分析,并用线性和logistic回归模型进行了白介素1β( 511)基因型与苯那普利疗效的相关性分析.在线性回归模型中,将病人治疗15天前后血压差值当作一连续变量,在logistic回归模型中,将患者对药物的反应当作二分变量进行分析.在回归分析中,对一些混杂因素进行了必要的调整.两种模型研究结果均发现:白介素1β( 511)基因型与两地区患者服用苯那普利15天后的收缩压和舒张压的降压幅度没有相关性.该结果提示白介素1β( 511)多态性可能不会对苯那普利的疗效产生影响.To examine whether interleukin1β gene (511) polymorphism is associated with therapeutic effect of a kind of angiotensin 1 converting enzyme inhibitors (ACEIs), benazepril. Individuals with essential hypertension were recruited from Yuexi County (n=594) and Huoqiu County (n=352), in Anhui, China, and were treated with benazepril for 15 consecutive days. Patients' blood pressure was measured and blood sample from subjects were collected. The interleukin1β (511) genotype was determined using the polymerase chain reactionrestriction fragment length polymorphism (PCRRFLP) analysis. Linear and logistic regressive analyses were conducted to test for the association between interleukin1βgenotype and drug response. In linear regression the blood pressure drop was considered as the dependent variable. In logistic regression the drug response was considered as a dichotomized trait. Covariates were adjusted in the regression models. Both Linear and logistic regression analyses showed that there is no association between interleukin1β (511) polymorphism and blood pressure drop after 15 days of benazepril treatment in samples from both Huoqiu and Yuexi. Combination of data from both places yielded similar results, this suggests that interleukin1β genotype probably does not affect the therapeutic effect of benazepril.

关 键 词：血管紧张素1转化酶抑制剂 白介素1Β 多态性 药物反应 高血压 血压 

分 类 号：R587.2[医药卫生—内分泌]