消心痛胶囊镇痛作用的实验研究  

An Experimental Study on the Analgesic Effects of Xiaoxintong Capsule on Pain Mode of Mice

作　　者：孙贵香[1] 彭芝配[1] 韩国栋[1] 滕久祥(指导)[1] 

机构地区：[1]湖南中医学院,湖南长沙410007

出　　处：《湖南中医学院学报》2003年第4期7-8,共2页Journal of Hunan College of Traditional Chinese Medicine

基　　金：湖南省卫生厅课题(2002006)

摘　　要：目的探讨消心痛胶囊的止痛作用。方法将 5 0只小鼠随机分为空白对照组、阳性对照组、消心痛胶囊低、中、高剂量组。采用热刺激法和化学刺激法造成 2种实验性疼痛模型 ,观察消心痛胶囊对热板致痛及醋酸致痛的影响 ,比较各组给药前后痛阈值及扭体反应次数 ,疼痛潜伏时间。结果消心痛胶囊各剂量组均能提高热板致痛小鼠的痛阈值 ,以中、高剂量组作用为显著 (P <0 .0 5 ) ;各剂量组均能减少醋酸致痛小鼠的扭体反应次数 ,延长疼痛潜伏时间 (P <0 .0 5 )。?Objective To investigate the analgesic effects of Xiaoxintong Capsule(XXTC). Methods 50 mice were randomly divided into 5 groups.i.e.blank controlling group (BCG),Positive controlling group(PCG) and 3 treating groups with various dosages of XXTC (TG). Then, pain models were prepared with the methods of chemical and heat stimuli respectively among the experimental animals and treating procedures were given to the animals respectively to investigate the analgesic effects of them on the experimental mice.Results Various dosages of XXTC all could elevate the pain threshold of experimental mice, while the analgesic effect was most significant among the animals treated with medium and higher dosages of XXTC (P< 0.05 ).Conclusion XXTC can bring about significant analgesic effects on the pain model of mice prepared by chemical and heat methods. 〔

关 键 词：消心痛胶囊 镇痛 小鼠 实验研究 

分 类 号：R285.5[医药卫生—中药学]