白藜三醇对血管内皮剥脱术后内膜增殖的影响  

Effect of Resveratrol on Intimal Hyperplasia after Endothelial Denudation in Experi-mental Rabbit Model

作　　者：邹建刚[1] 王志荣[1] 黄元铸[1] 杨国平[1] 冷静[2] 曹克将[1] 

机构地区：[1]南京医科大学第一附属医院心内科,江苏南京210029 [2]南京医科大学基础医学院,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2003年第5期470-472,共3页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的:观察白藜三醇对兔髂动脉内皮剥脱后血管内膜增殖的作用。方法:建立兔髂动脉内皮剥脱后血管内膜增殖模型,从术前1周至术后4周,给予2～4mg/(kg·d)的白藜三醇。结果:白藜三醇高剂量可有效地抑制血管内膜的增生,使内膜增生指数从模型组(M组)的0.41降低到白藜三醇高剂量组(H组)的0.28(P<0.01);相对管腔面积从M组的0.39增加到H组的0.53(P<0.001);相同管腔直径的增殖内膜中平滑肌细胞(SMC)数目从M组的1935减少到H组的1115(P<0.05)。结论:提示白藜三醇可抑制血管内膜的增殖,对于预防血管成形术后再狭窄可能具有潜在的临床应用价值。Objective:To investigate the effect of resveratrol on intimal thickening after endothelial denudation in experimental rabbit model. Methods: Intimal hyperplasia in rabbit iliac artery was established by denudating endothelium and resveratrol [2-4 mg/(kg*d)] was administered intragastrically for 5 weeks from 1 week before denudating. Results:At the higher concentration of resveratrol (H group), the intimal hyperplasia of injuried vascular wall was effectively inhibited; the intimal proliferation index was significantly less than that in the untreated model group (M group) (0.28 vs 0.41, P<0.01); the relative area of luminal increased from 0.39 in the M group to 0.53 in the H group (P<0.001); and the count of smooth muscle cell (SMC) in the thickened intima was more reduced in the H group than that in the M group (1 115 vs 1 935,P<0.05). Conclusions: The results suggest that resveratrol can effectively inhibit vascular intimal hyperplasia of injuried artery and it may be within the bounds of the possibility to prevent and treat the restenosis after angioplasty by resveratrol in clinical practice.

关 键 词：白藜三醇 内皮剥脱 血管内膜增生 血管平滑肌细胞生长 血管再狭窄 兔 

分 类 号：R972.6[医药卫生—药品] R543.5[医药卫生—药学]