水杨酸钠致耳蜗电生理改变  

The electro-physiological change of guinea pig cochlea caused by intracochlear perfusion of sodium salicylate

作　　者：张思毅[1] Don Robertson 

机构地区：[1]广东省人民医院耳鼻咽喉科,广州510100 [2]澳大利亚西澳大学医学院生理系听力实验室

出　　处：《临床耳鼻咽喉科杂志》2003年第9期551-553,共3页Journal of Clinical Otorhinolaryngology

摘　　要：目的 :了解水杨酸钠对耳蜗功能的影响 ,探讨其可能的作用机制。方法 :采用水杨酸钠在活体豚鼠耳蜗进行灌注 ,同时监测豚鼠耳蜗电位中的复合动作电位 (CAP)和总合电位 (SP)的阈值及输入 输出曲线变化 ,对耳蜗功能进行评估。结果 :水杨酸钠可引起CAP和SP阈值同步改变 ,两者的变化呈一一对应关系。结论 :水杨酸钠主要作用于耳蜗外毛细胞 ,通过影响外毛细胞的能动作用而影响耳蜗功能。Objective:To investigate the way how sodium salicylate affects cochlear function and discuss its possible mechanism. Method:Sodium salicylate was perfused through guinea pig cochlea. The thresholds and input-output (I/O) functions of compound action potential (CAP) and summating potential (SP) were monitored during the perfusion. Result:Sodium salicylate caused a significant change of CAP and SP threshold as well as I/O curve. The relationship between CAP and SP threshold change at 10 kHz during perfusion with 10 mmol/L salicylate tends to be 1∶1. Conclusion:Outer hair cells are most likely to be the sites of action of sodium salicylate and this action on the outer hair cell active process might lead to its ototoxicity.

关 键 词：水杨酸钠 耳蜗灌注 耳蜗电位 

分 类 号：R987[医药卫生—药品]