静脉输注脂肪乳剂对大鼠血清游离脂肪酸谱的影响  

The effect of fat emulsion intravenous infusion on serum free fatty acids in rats

作　　者：郑伟[1] 臧传波[1] 马冰[1] 李荣[1] 顾倬云[1] 

机构地区：[1]解放军总医院普外科,北京100853

出　　处：《中国普通外科杂志》2003年第8期594-596,共3页China Journal of General Surgery

基　　金：国家自然科学基金项目资助 (30 0 0 0 1 61)

摘　　要：目的　研究静脉输注脂肪乳剂对大鼠血清游离脂肪酸的影响。方法　将 2 4只雄性Wis tar大鼠随机分成 3组 ,每组 8只。 ( 1)对照组 (NS组 ) :输入生理盐水 ,正常饲养 ;( 2 )长链脂肪乳组(LCT组 ) :静脉输注 10 %长链脂肪乳剂intralipid ;( 3 )中长链脂肪乳组 (MCT /LCT组 ) :静脉输注中长链脂肪乳剂lipofundin。两脂肪乳剂组大鼠以等能量、等氮量、等液量匀速连续输入“全合一”肠外营养液。于第 8天取血标本进行血清游离脂肪酸测定。结果　两脂肪乳剂组各大鼠血清游离脂肪酸明显高于对照组 ,但两种脂肪乳组间差异无显著意义。结论　静脉输注脂肪乳剂能使大鼠血清游离脂肪酸明显升高。Objective To study the effect of fat emulsion intravenous infusion on serum free fatty acids(FFAs) in rats.Methods 24 male Wistar rats were divided randomly into 3 groups,8 rats in each group.(1)Control group(NS),the rats were infused with normal saline intravenously and regular chow;(2)Group LCT,infused with 10% intralipid fat emulsion intravenously;(3)Group MCT/LCT,infused with 10% lipofundin fat emulsion. Group LCT and group MCT/LCT were continuously received equal calorie,nitrogen and volemin in 'All-in-One'solutions. Serum samples were drawn on the 8th day after PN for fatty acid determination. Results The FFAs in Group LCT and group MCT/LCT were remarkably higher than that in control group, but no difference between Group LCT and group MCT/LCT. Conclusions Fat emulsion intravenous infusion can increase the serum free fatty acids considerately.

关 键 词：乳剂 脂肪/投药和剂量 输注 静脉内 脂肪酸谱 

分 类 号：R459.3[医药卫生—治疗学] R944.15[医药卫生—临床医学]